Discontinuation of immunosuppression for prevention of kidney graft rejection after receiving a bone marrow transplant from the same HLA identical sibling donor

James L. Gajewski, Cindy Ippoliti, Yan Ma, Richard Champlin

    Research output: Contribution to journalArticle

    9 Scopus citations

    Abstract

    Induction of tolerance in solid organ transplant recipients has been a long sought goal so that patients will not need lifelong immunosuppression. In this case report we review a patient who received a kidney transplant from an HLA matched related sibling and developed acute leukemia as a consequence of her immunosuppression. The patient was then treated with an allogeneic bone marrow transplant from her kidney donor. After the bone marrow transplant, all immunosuppression therapy for graft rejection and graft versus host disease was stopped. Six months after the bone marrow transplant, the patient's kidney function had no deterioration as a consequence of stopping immunosuppression. This illustrated that a combined solid organ/bone marrow transplant can help to induce tolerance. In fact, the tolerance to the bone marrow transplant for prevention of graft versus host disease may have been accomplished by the prior kidney transplant.

    Original languageEnglish (US)
    Pages (from-to)311-313
    Number of pages3
    JournalAmerican Journal of Hematology
    Volume71
    Issue number4
    DOIs
    StatePublished - Dec 1 2002

    Keywords

    • Bone marrow transplant
    • Kidney transplant
    • Tolerance

    ASJC Scopus subject areas

    • Hematology

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