Direct quantification of transmitral flow volume with dynamic 3-dimensional digital color Doppler: A validation study in an animal model

Rosemary A. Rusk, Xiang Ning Li, Yoshiki Mori, Timothy Irvine, Michael Jones, Arthur D. Zetts, Antoinette Kenny, David Sahn

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Accurately quantifying transmitral flow volume is clinically important not only as a measure of cardiac output, but also as a value from which to subtract aortic flow, for determining the severity of mitral regurgitation. However, controversy exists over the accuracy of pulsed Doppler for mitral flow quantification because of the complexity of mitral flow geometry and dynamic changes in flow profile and flow area. To explore the feasibility of directly quantifying transmitral flow volume with a newly developed dynamic 3-dimensional digital color Doppler technique, this in vivo experimental study was conducted to validate the method. Eight open chest sheep were imaged with a multiplane transesophageal (TEE) probe placed on the heart for digital 3-dimensional gated acquisition of mitral inflow over a 180-degree acquisition. The digital velocity data were contour detected for flow area after computing the velocity vectors and flow profile perpendicular to a spherical 3-dimensional surface across the mitral annulus. Flow areas and actual velocities were then integrated in time and space and the resulting flow volumes were compared with those obtained by a reference electromagnetic flowmeter on the aorta for 26 steady hemodynamic states. The flow volumes correlated closely to the electromagnetic references (y = 0.87x + 2.49, r = 0.92, SEE = 1.9 mL per beat). Our study shows that transmitral flow volume can be accurately determined in vivo by this dynamic 3-dimensional digital color Doppler flow quantification method.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalJournal of the American Society of Echocardiography
Volume15
Issue number1
DOIs
StatePublished - Jan 2002

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Validation Studies
Electromagnetic Phenomena
Animal Models
Color
Flowmeters
Mitral Valve Insufficiency
Cardiac Output
Aorta
Sheep
Thorax
Hemodynamics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Direct quantification of transmitral flow volume with dynamic 3-dimensional digital color Doppler : A validation study in an animal model. / Rusk, Rosemary A.; Li, Xiang Ning; Mori, Yoshiki; Irvine, Timothy; Jones, Michael; Zetts, Arthur D.; Kenny, Antoinette; Sahn, David.

In: Journal of the American Society of Echocardiography, Vol. 15, No. 1, 01.2002, p. 55-62.

Research output: Contribution to journalArticle

Rusk, Rosemary A. ; Li, Xiang Ning ; Mori, Yoshiki ; Irvine, Timothy ; Jones, Michael ; Zetts, Arthur D. ; Kenny, Antoinette ; Sahn, David. / Direct quantification of transmitral flow volume with dynamic 3-dimensional digital color Doppler : A validation study in an animal model. In: Journal of the American Society of Echocardiography. 2002 ; Vol. 15, No. 1. pp. 55-62.
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