Direct measurement of three-dimensionally reconstructed flow convergence surface area and regurgitant flow in aortic regurgitation

In vitro and chronic animal model studies

Takahiro Shiota, Michael Jones, Alain Delabays, Xiaokui Li, Izumi Yamada, Masahiro Ishii, Philippe Acar, Scott Holcomb, Natesa G. Pandian, David Sahn

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Evaluation of flow convergence (FC) with two-dimensional (2D) imaging systems may not be sufficiently accurate to characterize these often asymmetric, complex phenomena. The aim of this study was to validate a three-dimensional (3D) method for determining the severity of aortic regurgitation (AR) in an experimental animal model. Methods and Results: In six sheep with surgically induced chronic AR, 20 hemodynamically different states were studied. Instantaneous regurgitant flow rates were obtained by aortic and pulmonary electromagnetic flow meters. Video composite data of color Doppler flow mapping images were transferred into a TomTec computer after computer-controlled 180°rotational acquisition. Direct measurement of the 3D reconstructed FC surface areas as well as measurements of FC areas estimated with 2D methods with hemispherical and hemielliptical assumptions were performed, and values were multiplied by the aliasing velocity to obtain peak regurgitant flow rates. There was better agreement between 3D and electromagnetically derived flow rates than there was between the 2D and the reference values (r=.94, y=1.0x-0.16, difference=0.02 L/min for the 3D method; r=80, y=1.6x-0.3, difference=1.2 L/min for the 2D hemispherical method; r=.75, y=0.90x+0.2, difference=-0.20 L/min for the 2D hemielliptical method). Conclusions: Without any geometrical assumption, the 3D method provided better delineation of the FC zones and direct measurements of FC surface areas, permitting more accurate quantification of the severity of AR than the 2D methods.

Original languageEnglish (US)
Pages (from-to)3687-3695
Number of pages9
JournalCirculation
Volume96
Issue number10
StatePublished - Nov 18 1997
Externally publishedYes

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Aortic Valve Insufficiency
Animal Models
In Vitro Techniques
Electromagnetic Phenomena
Sheep
Reference Values
Color
Lung

Keywords

  • Blood flow
  • Doppler analysis
  • Echocardiography
  • Regurgitation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Direct measurement of three-dimensionally reconstructed flow convergence surface area and regurgitant flow in aortic regurgitation : In vitro and chronic animal model studies. / Shiota, Takahiro; Jones, Michael; Delabays, Alain; Li, Xiaokui; Yamada, Izumi; Ishii, Masahiro; Acar, Philippe; Holcomb, Scott; Pandian, Natesa G.; Sahn, David.

In: Circulation, Vol. 96, No. 10, 18.11.1997, p. 3687-3695.

Research output: Contribution to journalArticle

Shiota, T, Jones, M, Delabays, A, Li, X, Yamada, I, Ishii, M, Acar, P, Holcomb, S, Pandian, NG & Sahn, D 1997, 'Direct measurement of three-dimensionally reconstructed flow convergence surface area and regurgitant flow in aortic regurgitation: In vitro and chronic animal model studies', Circulation, vol. 96, no. 10, pp. 3687-3695.
Shiota, Takahiro ; Jones, Michael ; Delabays, Alain ; Li, Xiaokui ; Yamada, Izumi ; Ishii, Masahiro ; Acar, Philippe ; Holcomb, Scott ; Pandian, Natesa G. ; Sahn, David. / Direct measurement of three-dimensionally reconstructed flow convergence surface area and regurgitant flow in aortic regurgitation : In vitro and chronic animal model studies. In: Circulation. 1997 ; Vol. 96, No. 10. pp. 3687-3695.
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AU - Jones, Michael

AU - Delabays, Alain

AU - Li, Xiaokui

AU - Yamada, Izumi

AU - Ishii, Masahiro

AU - Acar, Philippe

AU - Holcomb, Scott

AU - Pandian, Natesa G.

AU - Sahn, David

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N2 - Background: Evaluation of flow convergence (FC) with two-dimensional (2D) imaging systems may not be sufficiently accurate to characterize these often asymmetric, complex phenomena. The aim of this study was to validate a three-dimensional (3D) method for determining the severity of aortic regurgitation (AR) in an experimental animal model. Methods and Results: In six sheep with surgically induced chronic AR, 20 hemodynamically different states were studied. Instantaneous regurgitant flow rates were obtained by aortic and pulmonary electromagnetic flow meters. Video composite data of color Doppler flow mapping images were transferred into a TomTec computer after computer-controlled 180°rotational acquisition. Direct measurement of the 3D reconstructed FC surface areas as well as measurements of FC areas estimated with 2D methods with hemispherical and hemielliptical assumptions were performed, and values were multiplied by the aliasing velocity to obtain peak regurgitant flow rates. There was better agreement between 3D and electromagnetically derived flow rates than there was between the 2D and the reference values (r=.94, y=1.0x-0.16, difference=0.02 L/min for the 3D method; r=80, y=1.6x-0.3, difference=1.2 L/min for the 2D hemispherical method; r=.75, y=0.90x+0.2, difference=-0.20 L/min for the 2D hemielliptical method). Conclusions: Without any geometrical assumption, the 3D method provided better delineation of the FC zones and direct measurements of FC surface areas, permitting more accurate quantification of the severity of AR than the 2D methods.

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KW - Blood flow

KW - Doppler analysis

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