Direct electron transfer between copper-containing proteins and electrodes

Sergey Shleev; Jan Tkac; Andreas Christenson; Tautgirdas Ruzgas; Alexander I. Yaropolov; James W. Whittaker; Lo Gorton

doi:10.1016/j.bios.2004.10.003

Direct electron transfer between copper-containing proteins and electrodes

Sergey Shleev, Jan Tkac, Andreas Christenson, Tautgirdas Ruzgas, Alexander I. Yaropolov, James W. Whittaker, Lo Gorton

Research output: Contribution to journal › Review article › peer-review

541 Scopus citations

Abstract

The electrochemistry of some copper-containing proteins and enzymes, viz. azurin, galactose oxidase, tyrosinase (catechol oxidase), and the "blue" multicopper oxidases (ascorbate oxidase, bilirubin oxidase, ceruloplasmin, laccase) is reviewed and discussed in conjunction with their basic biochemical and structural characteristics. It is shown that long-range electron transfer between these enzymes and electrodes can be established, and the mechanistic schemes of the DET processes are proposed.

Original language	English (US)
Pages (from-to)	2517-2554
Number of pages	38
Journal	Biosensors and Bioelectronics
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.bios.2004.10.003
State	Published - Jun 15 2005
Externally published	Yes

Keywords

Ascorbate oxidase
Azurin
Bilirubin oxidase
Ceruloplasmin
Direct electron transfer
Galactose oxidase
Gold electrode
Graphite electrode
Hemocyanin
Laccase
Redox potential
T1, T2 and T3 sites
Tyrosinase

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

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10.1016/j.bios.2004.10.003

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title = "Direct electron transfer between copper-containing proteins and electrodes",

abstract = "The electrochemistry of some copper-containing proteins and enzymes, viz. azurin, galactose oxidase, tyrosinase (catechol oxidase), and the {"}blue{"} multicopper oxidases (ascorbate oxidase, bilirubin oxidase, ceruloplasmin, laccase) is reviewed and discussed in conjunction with their basic biochemical and structural characteristics. It is shown that long-range electron transfer between these enzymes and electrodes can be established, and the mechanistic schemes of the DET processes are proposed.",

keywords = "Ascorbate oxidase, Azurin, Bilirubin oxidase, Ceruloplasmin, Direct electron transfer, Galactose oxidase, Gold electrode, Graphite electrode, Hemocyanin, Laccase, Redox potential, T1, T2 and T3 sites, Tyrosinase",

author = "Sergey Shleev and Jan Tkac and Andreas Christenson and Tautgirdas Ruzgas and Yaropolov, {Alexander I.} and Whittaker, {James W.} and Lo Gorton",

note = "Funding Information: The authors thank the following organisations for financial support. The Swedish Research Council (Vetenskapsr{\aa}det), The European Commission (INCO project, contract No. ICA2-CT-2000-10050 and Marie Curie Individual Fellowship, contract No. QLK6-CT-2002-51580), The Wenner-Gren Foundations, The Swedish Institute, the Russian Foundation for Basic Research (project Nos. 02-04-48885 and 03-04-48937) and the National Institutes of Health (GM 46749).",

year = "2005",

month = jun,

day = "15",

doi = "10.1016/j.bios.2004.10.003",

language = "English (US)",

volume = "20",

pages = "2517--2554",

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TY - JOUR

T1 - Direct electron transfer between copper-containing proteins and electrodes

AU - Shleev, Sergey

AU - Tkac, Jan

AU - Christenson, Andreas

AU - Ruzgas, Tautgirdas

AU - Yaropolov, Alexander I.

AU - Whittaker, James W.

AU - Gorton, Lo

N1 - Funding Information: The authors thank the following organisations for financial support. The Swedish Research Council (Vetenskapsrådet), The European Commission (INCO project, contract No. ICA2-CT-2000-10050 and Marie Curie Individual Fellowship, contract No. QLK6-CT-2002-51580), The Wenner-Gren Foundations, The Swedish Institute, the Russian Foundation for Basic Research (project Nos. 02-04-48885 and 03-04-48937) and the National Institutes of Health (GM 46749).

PY - 2005/6/15

Y1 - 2005/6/15

N2 - The electrochemistry of some copper-containing proteins and enzymes, viz. azurin, galactose oxidase, tyrosinase (catechol oxidase), and the "blue" multicopper oxidases (ascorbate oxidase, bilirubin oxidase, ceruloplasmin, laccase) is reviewed and discussed in conjunction with their basic biochemical and structural characteristics. It is shown that long-range electron transfer between these enzymes and electrodes can be established, and the mechanistic schemes of the DET processes are proposed.

AB - The electrochemistry of some copper-containing proteins and enzymes, viz. azurin, galactose oxidase, tyrosinase (catechol oxidase), and the "blue" multicopper oxidases (ascorbate oxidase, bilirubin oxidase, ceruloplasmin, laccase) is reviewed and discussed in conjunction with their basic biochemical and structural characteristics. It is shown that long-range electron transfer between these enzymes and electrodes can be established, and the mechanistic schemes of the DET processes are proposed.

KW - Ascorbate oxidase

KW - Azurin

KW - Bilirubin oxidase

KW - Ceruloplasmin

KW - Direct electron transfer

KW - Galactose oxidase

KW - Gold electrode

KW - Graphite electrode

KW - Hemocyanin

KW - Laccase

KW - Redox potential

KW - T1, T2 and T3 sites

KW - Tyrosinase

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U2 - 10.1016/j.bios.2004.10.003

DO - 10.1016/j.bios.2004.10.003

M3 - Review article

C2 - 15854824

AN - SCOPUS:18144407596

SN - 0956-5663

VL - 20

SP - 2517

EP - 2554

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

IS - 12

ER -

Direct electron transfer between copper-containing proteins and electrodes

Abstract

Keywords

ASJC Scopus subject areas

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