Sutton et. al. show that re-expression of DIRAS3 can inhibit the growth of multiple cancer types driven by K-RAS mutations by a direct interaction and disruption of K-RAS higher ordered clusters. This phenotype is driven by an N-terminal extension, which distinguishes DIRAS3 from other RAS-related small GTPases.
- ovarian cancer
- pancreatic cancer
- RAS inhibitor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)