Diffusion-weighted MR imaging and MR spectroscopy in glutaric aciduria type 1

K. K. Oguz, A. Ozturk, A. Cila

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Although conventional magnetic resonance imaging (MRI) findings of glutaric aciduria type 1 (GA-1) have been well established, diffusion weighted MR imaging (DWI) and proton MR spectroscopy (MRS) findings are limited. We report widespread restricted diffusion in the white matter and increased diffusion in bilateral putamen in a case of GA-1. The MRS showed decreased N-acetyl-aspartate (NAA)/creatine (Cr) ratio compared with a sex and age-matched control with no significant change in choline (Cho)/Cr ratio. The presence of the lactate peak reflecting disturbed mitochondrial functions in this disease has never been reported.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalNeuroradiology
Volume47
Issue number3
DOIs
StatePublished - Mar 1 2005

    Fingerprint

Keywords

  • Diffusion-weighted MR imaging
  • Glutaric aciduria type 1
  • Magnetic resonance imaging
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this