Abstract
Although conventional magnetic resonance imaging (MRI) findings of glutaric aciduria type 1 (GA-1) have been well established, diffusion weighted MR imaging (DWI) and proton MR spectroscopy (MRS) findings are limited. We report widespread restricted diffusion in the white matter and increased diffusion in bilateral putamen in a case of GA-1. The MRS showed decreased N-acetyl-aspartate (NAA)/creatine (Cr) ratio compared with a sex and age-matched control with no significant change in choline (Cho)/Cr ratio. The presence of the lactate peak reflecting disturbed mitochondrial functions in this disease has never been reported.
Original language | English (US) |
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Pages (from-to) | 229-234 |
Number of pages | 6 |
Journal | Neuroradiology |
Volume | 47 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2005 |
Externally published | Yes |
Keywords
- Diffusion-weighted MR imaging
- Glutaric aciduria type 1
- Magnetic resonance imaging
- Proton magnetic resonance spectroscopy
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
- Cardiology and Cardiovascular Medicine