Diffusion tensor imaging of the pediatric optic nerve

Intrinsic and extrinsic pathology compared to normal controls

Joshua Nickerson, Michael B. Salmela, Chris J. Koski, Trevor Andrews, Christopher G. Filippi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: To establish normative magnetic resonance diffusion tensor imaging (MRDTI) data in the pediatric optic nerve and compare to pathologic conditions both intrinsic and extrinsic to the anterior optic nerve pathway. Materials and Methods: A retrospective analysis of MRDTI at 3.0T in children ages 0-18 with both normal imaging studies and with pathologic conditions either arising from the optic nerves or exerting mass effect on the anterior optic pathways was performed. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were obtained within the posterior part of the intraorbital optic nerves. Statistical analysis compared normal controls to optic pathway lesions. Results: Lesions intrinsic to the optic nerve including septo-optic dysplasia and optic nerve glioma demonstrated statistically significant reductions in FA and increases in ADC values. There was no statistically significant difference in FA or mean diffusivity between the normal controls and patients with lesions extrinsic to the optic nerve but exerting mass effect on the visual pathway. Conclusion: MRDTI is a feasible technique for evaluating the optic nerves in pediatric patients. It may play a role in presurgical planning by demonstrating integrity of the visual pathway in patients with resectable lesions, allowing for minimization of morbidity associated with vision loss.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Diffusion Tensor Imaging
Optic Nerve
Pediatrics
Pathology
Anisotropy
Magnetic Resonance Spectroscopy
Visual Pathways
Septo-Optic Dysplasia
Optic Nerve Glioma
Morbidity

Keywords

  • Diffusion tensor imaging
  • Fractional anisotropy
  • Optic nerve
  • Pediatrics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diffusion tensor imaging of the pediatric optic nerve : Intrinsic and extrinsic pathology compared to normal controls. / Nickerson, Joshua; Salmela, Michael B.; Koski, Chris J.; Andrews, Trevor; Filippi, Christopher G.

In: Journal of Magnetic Resonance Imaging, Vol. 32, No. 1, 01.01.2010, p. 76-81.

Research output: Contribution to journalArticle

Nickerson, Joshua ; Salmela, Michael B. ; Koski, Chris J. ; Andrews, Trevor ; Filippi, Christopher G. / Diffusion tensor imaging of the pediatric optic nerve : Intrinsic and extrinsic pathology compared to normal controls. In: Journal of Magnetic Resonance Imaging. 2010 ; Vol. 32, No. 1. pp. 76-81.
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