Abstract
Background: We have analyzed our experience with differentiated thyroid cancer patients with extrathyroidal extension (ETE) to investigate patterns of recurrence and define factors that predict failure. Patients and methods: The records of 1,012 patients treated surgically from 1930 to 1985 were reviewed. A total of 79 patients (8%) had ETE. The median length of follow-up was 10 years. Results: Patients with ETE were more likely to fail treatment and to die of their disease than were patients without ETE (77% versus 34% and 71% versus 13%, respectively; P 45, tumor size >4 cm, and incomplete excision (P ≦0.05). After stratification for age, survival in older patients was not affected by tumor size or incomplete excision, while in younger patients tumor size or the presence of distant metastasis did not adversely affect survival. Patients younger than 45 with negative margins had similar survival to patients without ETE (P = 0.46). Conclusions: Patients with ETE are more likely to die of their disease and to fail at all sites. Survival in older patients was not affected by incomplete excision while it was in younger patients. The presence of distant metastasis did not affect survival in younger patients. Our results suggest that among patients under 45, the presence of ETE does not adversely impact upon survival when the primary tumor is completely resected.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 467-470 |
| Number of pages | 4 |
| Journal | The American Journal of Surgery |
| Volume | 170 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1995 |
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ASJC Scopus subject areas
- Surgery
Cite this
Differentiated carcinoma of the thyroid with extrathyroidal extension. / Andersen, Peter; Kinsella, John; Loree, Thom R.; Shaha, Ashok R.; Shah, Jatin P.
In: The American Journal of Surgery, Vol. 170, No. 5, 1995, p. 467-470.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differentiated carcinoma of the thyroid with extrathyroidal extension
AU - Andersen, Peter
AU - Kinsella, John
AU - Loree, Thom R.
AU - Shaha, Ashok R.
AU - Shah, Jatin P.
PY - 1995
Y1 - 1995
N2 - Background: We have analyzed our experience with differentiated thyroid cancer patients with extrathyroidal extension (ETE) to investigate patterns of recurrence and define factors that predict failure. Patients and methods: The records of 1,012 patients treated surgically from 1930 to 1985 were reviewed. A total of 79 patients (8%) had ETE. The median length of follow-up was 10 years. Results: Patients with ETE were more likely to fail treatment and to die of their disease than were patients without ETE (77% versus 34% and 71% versus 13%, respectively; P 45, tumor size >4 cm, and incomplete excision (P ≦0.05). After stratification for age, survival in older patients was not affected by tumor size or incomplete excision, while in younger patients tumor size or the presence of distant metastasis did not adversely affect survival. Patients younger than 45 with negative margins had similar survival to patients without ETE (P = 0.46). Conclusions: Patients with ETE are more likely to die of their disease and to fail at all sites. Survival in older patients was not affected by incomplete excision while it was in younger patients. The presence of distant metastasis did not affect survival in younger patients. Our results suggest that among patients under 45, the presence of ETE does not adversely impact upon survival when the primary tumor is completely resected.
AB - Background: We have analyzed our experience with differentiated thyroid cancer patients with extrathyroidal extension (ETE) to investigate patterns of recurrence and define factors that predict failure. Patients and methods: The records of 1,012 patients treated surgically from 1930 to 1985 were reviewed. A total of 79 patients (8%) had ETE. The median length of follow-up was 10 years. Results: Patients with ETE were more likely to fail treatment and to die of their disease than were patients without ETE (77% versus 34% and 71% versus 13%, respectively; P 45, tumor size >4 cm, and incomplete excision (P ≦0.05). After stratification for age, survival in older patients was not affected by tumor size or incomplete excision, while in younger patients tumor size or the presence of distant metastasis did not adversely affect survival. Patients younger than 45 with negative margins had similar survival to patients without ETE (P = 0.46). Conclusions: Patients with ETE are more likely to die of their disease and to fail at all sites. Survival in older patients was not affected by incomplete excision while it was in younger patients. The presence of distant metastasis did not affect survival in younger patients. Our results suggest that among patients under 45, the presence of ETE does not adversely impact upon survival when the primary tumor is completely resected.
UR - http://www.scopus.com/inward/record.url?scp=0028856074&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028856074&partnerID=8YFLogxK
U2 - 10.1016/S0002-9610(99)80331-6
DO - 10.1016/S0002-9610(99)80331-6
M3 - Article
C2 - 7485734
AN - SCOPUS:0028856074
VL - 170
SP - 467
EP - 470
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 5
ER -