Differential entrainment of a social rhythm in adolescent mice

Jules B. Panksepp, Jenny C. Wong, Bruce C. Kennedy, Garet Lahvis

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Daily routines in animal activities range from sleep-wake cycles, to foraging bouts, to social interactions. Among animals living within groups, it is unclear whether the motivations that underlie social interactions respond to daily light-dark (LD) cycles or endogenous circadian rhythms. Employing two mouse strains (BALB/cJ [BALB] and C57BL/6J [B6]) with genetically based differences in social affect and circadian rhythms, we examined how social investigation (SI) is modulated by social deprivation and circadian factors. We found a genetic influence on SI that was moderated by the preceding duration of social deprivation, requiring 3-6 h of social isolation prior to testing. Following 6 h of social deprivation, the SI responses of adolescent B6 mice were greater than those of BALB mice only when the isolation period was imposed during the dark phase of the LD cycle. When B6 mice were weaned into conditions of constant darkness, a novel, endogenous social rhythm emerged, which was characterized by two pronounced peaks of social responsiveness (relative to one peak under LD entrainment) that were separated by 12-h intervals. Irrespective of the lighting conditions during social isolation, the SI responses of adolescent BALB mice did not oscillate across the day. Similar strain-dependent patterns of sociability were evident within groups of mice that were left undisturbed in their home cage under LD entrainment or constant darkness. Overall, genetic influences on the social phenotypes of adolescent mice are thus moderated by an interaction between social deprivation and oscillations of an endogenous social rhythm that entrains to the LD cycle.

Original languageEnglish (US)
Pages (from-to)239-245
Number of pages7
JournalBehavioural Brain Research
Volume195
Issue number2
DOIs
StatePublished - Dec 22 2008

Fingerprint

Photoperiod
Interpersonal Relations
Social Isolation
Darkness
Circadian Rhythm
Light
Lighting
Motivation
Sleep
Phenotype

Keywords

  • Behavior
  • Chronobiology
  • Circadian biology
  • Circadian rhythm
  • Mus musculus
  • Social motivation
  • Social neuroscience

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Differential entrainment of a social rhythm in adolescent mice. / Panksepp, Jules B.; Wong, Jenny C.; Kennedy, Bruce C.; Lahvis, Garet.

In: Behavioural Brain Research, Vol. 195, No. 2, 22.12.2008, p. 239-245.

Research output: Contribution to journalArticle

Panksepp, Jules B. ; Wong, Jenny C. ; Kennedy, Bruce C. ; Lahvis, Garet. / Differential entrainment of a social rhythm in adolescent mice. In: Behavioural Brain Research. 2008 ; Vol. 195, No. 2. pp. 239-245.
@article{3096ec269b66489281e0260ce9a634fc,
title = "Differential entrainment of a social rhythm in adolescent mice",
abstract = "Daily routines in animal activities range from sleep-wake cycles, to foraging bouts, to social interactions. Among animals living within groups, it is unclear whether the motivations that underlie social interactions respond to daily light-dark (LD) cycles or endogenous circadian rhythms. Employing two mouse strains (BALB/cJ [BALB] and C57BL/6J [B6]) with genetically based differences in social affect and circadian rhythms, we examined how social investigation (SI) is modulated by social deprivation and circadian factors. We found a genetic influence on SI that was moderated by the preceding duration of social deprivation, requiring 3-6 h of social isolation prior to testing. Following 6 h of social deprivation, the SI responses of adolescent B6 mice were greater than those of BALB mice only when the isolation period was imposed during the dark phase of the LD cycle. When B6 mice were weaned into conditions of constant darkness, a novel, endogenous social rhythm emerged, which was characterized by two pronounced peaks of social responsiveness (relative to one peak under LD entrainment) that were separated by 12-h intervals. Irrespective of the lighting conditions during social isolation, the SI responses of adolescent BALB mice did not oscillate across the day. Similar strain-dependent patterns of sociability were evident within groups of mice that were left undisturbed in their home cage under LD entrainment or constant darkness. Overall, genetic influences on the social phenotypes of adolescent mice are thus moderated by an interaction between social deprivation and oscillations of an endogenous social rhythm that entrains to the LD cycle.",
keywords = "Behavior, Chronobiology, Circadian biology, Circadian rhythm, Mus musculus, Social motivation, Social neuroscience",
author = "Panksepp, {Jules B.} and Wong, {Jenny C.} and Kennedy, {Bruce C.} and Garet Lahvis",
year = "2008",
month = "12",
day = "22",
doi = "10.1016/j.bbr.2008.09.010",
language = "English (US)",
volume = "195",
pages = "239--245",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Differential entrainment of a social rhythm in adolescent mice

AU - Panksepp, Jules B.

AU - Wong, Jenny C.

AU - Kennedy, Bruce C.

AU - Lahvis, Garet

PY - 2008/12/22

Y1 - 2008/12/22

N2 - Daily routines in animal activities range from sleep-wake cycles, to foraging bouts, to social interactions. Among animals living within groups, it is unclear whether the motivations that underlie social interactions respond to daily light-dark (LD) cycles or endogenous circadian rhythms. Employing two mouse strains (BALB/cJ [BALB] and C57BL/6J [B6]) with genetically based differences in social affect and circadian rhythms, we examined how social investigation (SI) is modulated by social deprivation and circadian factors. We found a genetic influence on SI that was moderated by the preceding duration of social deprivation, requiring 3-6 h of social isolation prior to testing. Following 6 h of social deprivation, the SI responses of adolescent B6 mice were greater than those of BALB mice only when the isolation period was imposed during the dark phase of the LD cycle. When B6 mice were weaned into conditions of constant darkness, a novel, endogenous social rhythm emerged, which was characterized by two pronounced peaks of social responsiveness (relative to one peak under LD entrainment) that were separated by 12-h intervals. Irrespective of the lighting conditions during social isolation, the SI responses of adolescent BALB mice did not oscillate across the day. Similar strain-dependent patterns of sociability were evident within groups of mice that were left undisturbed in their home cage under LD entrainment or constant darkness. Overall, genetic influences on the social phenotypes of adolescent mice are thus moderated by an interaction between social deprivation and oscillations of an endogenous social rhythm that entrains to the LD cycle.

AB - Daily routines in animal activities range from sleep-wake cycles, to foraging bouts, to social interactions. Among animals living within groups, it is unclear whether the motivations that underlie social interactions respond to daily light-dark (LD) cycles or endogenous circadian rhythms. Employing two mouse strains (BALB/cJ [BALB] and C57BL/6J [B6]) with genetically based differences in social affect and circadian rhythms, we examined how social investigation (SI) is modulated by social deprivation and circadian factors. We found a genetic influence on SI that was moderated by the preceding duration of social deprivation, requiring 3-6 h of social isolation prior to testing. Following 6 h of social deprivation, the SI responses of adolescent B6 mice were greater than those of BALB mice only when the isolation period was imposed during the dark phase of the LD cycle. When B6 mice were weaned into conditions of constant darkness, a novel, endogenous social rhythm emerged, which was characterized by two pronounced peaks of social responsiveness (relative to one peak under LD entrainment) that were separated by 12-h intervals. Irrespective of the lighting conditions during social isolation, the SI responses of adolescent BALB mice did not oscillate across the day. Similar strain-dependent patterns of sociability were evident within groups of mice that were left undisturbed in their home cage under LD entrainment or constant darkness. Overall, genetic influences on the social phenotypes of adolescent mice are thus moderated by an interaction between social deprivation and oscillations of an endogenous social rhythm that entrains to the LD cycle.

KW - Behavior

KW - Chronobiology

KW - Circadian biology

KW - Circadian rhythm

KW - Mus musculus

KW - Social motivation

KW - Social neuroscience

UR - http://www.scopus.com/inward/record.url?scp=54249089829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54249089829&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2008.09.010

DO - 10.1016/j.bbr.2008.09.010

M3 - Article

C2 - 18840476

AN - SCOPUS:54249089829

VL - 195

SP - 239

EP - 245

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -