Dietary therapy mitigates persistent wake deficits caused by mild traumatic brain injury

Miranda Lim, Jaclynn Elkind, Guoxiang Xiong, Ray Galante, Jingxu Zhu, Lin Zhang, Jie Lian, Julianna Rodin, Nicholas N. Kuzma, Allan I. Pack, Akiva S. Cohen

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Sleep disorders are highly prevalent in patients with traumatic brain injury (TBI) and can significantly impair cognitive rehabilitation. No proven therapies exist to mitigate the neurocognitive consequences of TBI. We show that mild brain injury in mice causes a persistent inability to maintain wakefulness and decreases orexin neuron activation during wakefulness. We gave mice a dietary supplement of branched-chain amino acids (BCAAs), precursors for de novo glutamate synthesis in the brain. BCAA therapy reinstated activation of orexin neurons and improved wake deficits in mice with mild brain injury. Our data suggest that dietary BCAA intervention, acting in part through orexin, can ameliorate injury-induced sleep disturbances and may facilitate cognitive rehabilitation after brain injury.

Original languageEnglish (US)
Article number215ra173
JournalScience Translational Medicine
Volume5
Issue number215
DOIs
StatePublished - Dec 11 2013

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Brain Concussion
Branched Chain Amino Acids
Brain Injuries
Wakefulness
Rehabilitation
Neurons
Dietary Supplements
Glutamic Acid
Sleep
Therapeutics
Wounds and Injuries
Brain
Traumatic Brain Injury

ASJC Scopus subject areas

  • Medicine(all)

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Dietary therapy mitigates persistent wake deficits caused by mild traumatic brain injury. / Lim, Miranda; Elkind, Jaclynn; Xiong, Guoxiang; Galante, Ray; Zhu, Jingxu; Zhang, Lin; Lian, Jie; Rodin, Julianna; Kuzma, Nicholas N.; Pack, Allan I.; Cohen, Akiva S.

In: Science Translational Medicine, Vol. 5, No. 215, 215ra173, 11.12.2013.

Research output: Contribution to journalArticle

Lim, M, Elkind, J, Xiong, G, Galante, R, Zhu, J, Zhang, L, Lian, J, Rodin, J, Kuzma, NN, Pack, AI & Cohen, AS 2013, 'Dietary therapy mitigates persistent wake deficits caused by mild traumatic brain injury', Science Translational Medicine, vol. 5, no. 215, 215ra173. https://doi.org/10.1126/scitranslmed.3007092
Lim, Miranda ; Elkind, Jaclynn ; Xiong, Guoxiang ; Galante, Ray ; Zhu, Jingxu ; Zhang, Lin ; Lian, Jie ; Rodin, Julianna ; Kuzma, Nicholas N. ; Pack, Allan I. ; Cohen, Akiva S. / Dietary therapy mitigates persistent wake deficits caused by mild traumatic brain injury. In: Science Translational Medicine. 2013 ; Vol. 5, No. 215.
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