Dietary protein intake and progressive glomerular sclerosis: The role of capillary hypertension and hyperperfusion in the progression of renal disease

T. W. Meyer, S. Anderson, B. M. Brenner

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Unrestricted intake of protein-rich foods is accompanied by sustained increases in glomerular capillary pressures and flows. Intrarenal hypertension and hyperperfusion associated with protein intake may eventually cause glomerular sclerosis and account for decreased renal function seen with aging. Further elevation of glomerular capillary pressures and flows contributes to progressive glomerular destruction and eventual loss of renal function when nephron number has been reduced by renal disease. Progressive loss of renal function may be retarded by restriction of protein intake. Protein restriction appears to preserve renal function by limiting intrarenal capillary hypertension and hyperperfusion.

Original languageEnglish (US)
Pages (from-to)832-838
Number of pages7
JournalAnnals of internal medicine
Volume98
Issue number5 Suppl.
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Internal Medicine

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