An increase in calcium intake has been proposed as a non-pharmacological treatment of high BP. Moreover, an inverse relationship has been observed between bone mineral content and BP. We therefore postulated that dietary Ca2+ improves Ca2+ homeostasis, restoring BMD and BP to normal, and measured BP (mmHg), BMD (mg/area), calcitriol (D, pg/ml), PTH (pg/ml), ionized Ca2+ (iCa, mM) and CaBP-9K (μg/mg, a marker of intestinal Ca2+ transport) in SHR fed 0.1%, 0.2%, 1.0% or 2.0% Ca2+ diets for 6 weeks (n=16/group, half SHR provided by Taconic (T), and half by Chartes River (CR). Results were: (*, p<0.05, ANOVA) m±SEM 0.1% Ca 0.2% Ca 1.0% Ca 2.0% Ca BP* 212.6±4.0 211.9±3.8 200.1±3.8 176.6±4.7 iCa * 1.26±0.02 1.33±0.01 1.35±0.01 1.34±0.01 D * 503.5±7.0 182.2±8.2 92.9±4.7 96.2±3.3 CaBP * 34.6±1.7 28.1±1.5 20.4±1.1 17.4±1.1 BMD * 89±2 108±2 133±2 135±2 PTH T * 211.5±25.8 164.9±21.8 106.9±10.2 83.4±11.4 CR 134.0±46.0 118.6±24.2 159.7±20.1 105.1±12.5 The following correlations were found: iCa/D (P<0.0001, r=-0.54); iCa/PTH (p<0.0002, r=-0.48), BMD/D (p<0.0001, r=-0.84), BMD/BP (p<0.0006, r=-0.47), BMD/CABP (p<0.0001, r=-0.75), and D/CaBP (p<0.0001, r=0.70). The data suggest that increased calcium intake improves calcium homeostasis as well as systemic BP and BMD, thus supporting the hypothesis that essential hypertension can be successfully treated with adequate Ca2+ intake.
|Original language||English (US)|
|State||Published - Dec 1 1997|
ASJC Scopus subject areas
- Molecular Biology