Dietary calcium improves bone mineral density (BMD) and lowers blood pressure (BP) in spontaneously hypertensive rats (SHR)

C. M. Roullet, E. Orwoll, J. B. Roullet, Q. Yue, D. A. McCarron, D. C. Hatton

Research output: Contribution to journalArticlepeer-review

Abstract

An increase in calcium intake has been proposed as a non-pharmacological treatment of high BP. Moreover, an inverse relationship has been observed between bone mineral content and BP. We therefore postulated that dietary Ca2+ improves Ca2+ homeostasis, restoring BMD and BP to normal, and measured BP (mmHg), BMD (mg/area), calcitriol (D, pg/ml), PTH (pg/ml), ionized Ca2+ (iCa, mM) and CaBP-9K (μg/mg, a marker of intestinal Ca2+ transport) in SHR fed 0.1%, 0.2%, 1.0% or 2.0% Ca2+ diets for 6 weeks (n=16/group, half SHR provided by Taconic (T), and half by Chartes River (CR). Results were: (*, p<0.05, ANOVA) m±SEM 0.1% Ca 0.2% Ca 1.0% Ca 2.0% Ca BP* 212.6±4.0 211.9±3.8 200.1±3.8 176.6±4.7 iCa * 1.26±0.02 1.33±0.01 1.35±0.01 1.34±0.01 D * 503.5±7.0 182.2±8.2 92.9±4.7 96.2±3.3 CaBP * 34.6±1.7 28.1±1.5 20.4±1.1 17.4±1.1 BMD * 89±2 108±2 133±2 135±2 PTH T * 211.5±25.8 164.9±21.8 106.9±10.2 83.4±11.4 CR 134.0±46.0 118.6±24.2 159.7±20.1 105.1±12.5 The following correlations were found: iCa/D (P<0.0001, r=-0.54); iCa/PTH (p<0.0002, r=-0.48), BMD/D (p<0.0001, r=-0.84), BMD/BP (p<0.0006, r=-0.47), BMD/CABP (p<0.0001, r=-0.75), and D/CaBP (p<0.0001, r=0.70). The data suggest that increased calcium intake improves calcium homeostasis as well as systemic BP and BMD, thus supporting the hypothesis that essential hypertension can be successfully treated with adequate Ca2+ intake.

Original languageEnglish (US)
Pages (from-to)A468
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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