Diagnostic value of creatine kinase and creatine kinase MB isoenzyme in chronic hemodialysis patients: A longitudinal study

T. R. Green, T. A. Golper, R. D. Swenson, J. P. Pulliam, C. D. Morris

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Serial measurements of total creatine kinase (CK) and the MB isoenzyme of CK (CK-MB) were performed on 18 stable hemodialysis patients over a 36 month interval in a longitudinal study designed to examine CK and CK-MB variability. Totak CK was measured by the DuPont ACA pack procedure. CK-MB was quantitated by the ACA CK-MB ion exchange pack procedure, and by electrophoresis. The mean CK level was 242 ± 179 IU/l (± SD). The mean CK-MB level was approximately 8% of the total CK. Seventy-two percent of the patients had at least one elevated CK level during the course of this study. Depending upon the method of analysis, 88 to 100% of the patients had at least one elevated CK-MB level. Marked and sporadic variations in both total CK and CK-MB levels were apparent, but were not related to the assay. Patients receiving long-term intramuscular androgens had higher CK, but not CK-MB, than did hemodialysis patients not receiving these agents. Discontinuation of the intramuscular androgens for four weeks led to a fall in CK in only one of four patients. Therefore there appears to be a biological effect of exogenous androgens which may play a role in elevating CK in hemodialysis patients.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalClinical Nephrology
Volume25
Issue number1
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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