Diagnostic imaging of malignant melanoma with radiolabeled antitumor antibodies

S. M. Larson; J. A. Carrasquillo; K. A. Krohn; R. W. McGuffin; D. L. Williams; I. Hellström; D. Lyster

doi:10.1001/jama.249.6.811

Diagnostic imaging of malignant melanoma with radiolabeled antitumor antibodies

S. M. Larson, J. A. Carrasquillo, K. A. Krohn, R. W. McGuffin, D. L. Williams, I. Hellström, D. Lyster

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Abstract

Tumor-specific monoclonal antibodies offer the potential for improved diagnosis of and therapy for malignant neoplasms. We have used iodine 131- and iodine 123-radiolabeled murine monoclonal immunoglobulin and Fab fragments against p97, a 97,000 molecular weight, melanoma-associated antigen on the cell surface, to image metastatic tumor deposits in patients with malignant melanoma.

Original language	English (US)
Pages (from-to)	811-812
Number of pages	2
Journal	Journal of the American Medical Association
Volume	249
Issue number	6
DOIs	https://doi.org/10.1001/jama.249.6.811
State	Published - Sep 1 1983
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1001/jama.249.6.811

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abstract = "Tumor-specific monoclonal antibodies offer the potential for improved diagnosis of and therapy for malignant neoplasms. We have used iodine 131- and iodine 123-radiolabeled murine monoclonal immunoglobulin and Fab fragments against p97, a 97,000 molecular weight, melanoma-associated antigen on the cell surface, to image metastatic tumor deposits in patients with malignant melanoma.",

author = "Larson, {S. M.} and Carrasquillo, {J. A.} and Krohn, {K. A.} and McGuffin, {R. W.} and Williams, {D. L.} and I. Hellstr{\"o}m and D. Lyster",

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AU - Williams, D. L.

AU - Hellström, I.

AU - Lyster, D.

PY - 1983/9/1

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N2 - Tumor-specific monoclonal antibodies offer the potential for improved diagnosis of and therapy for malignant neoplasms. We have used iodine 131- and iodine 123-radiolabeled murine monoclonal immunoglobulin and Fab fragments against p97, a 97,000 molecular weight, melanoma-associated antigen on the cell surface, to image metastatic tumor deposits in patients with malignant melanoma.

AB - Tumor-specific monoclonal antibodies offer the potential for improved diagnosis of and therapy for malignant neoplasms. We have used iodine 131- and iodine 123-radiolabeled murine monoclonal immunoglobulin and Fab fragments against p97, a 97,000 molecular weight, melanoma-associated antigen on the cell surface, to image metastatic tumor deposits in patients with malignant melanoma.

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Diagnostic imaging of malignant melanoma with radiolabeled antitumor antibodies

Abstract

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