Diagnostic accuracy of rapid tests for sexually transmitted infections in symptomatic women

Lilian Nuñez-Forero, Luisa Moyano-Ariza, Hernando Gaitán-Duarte, Edith Ángel-Müller, Ariel Ruiz-Parra, Patricia González, Andrea Rodríguez, Jorge Tolosa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective To determine the diagnostic accuracy of tests developed for use at the point of care for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and syphilis in women having symptoms of lower urinary tract infection. Methods Cross-sectional study involving sexually active 14-49-year-old women with lower urinary tract infection symptoms consulting during 2010 at a private health clinic and at two public hospitals in Bogotá, Colombia. Pregnant women, those with a previous hysterectomy or those who received antibiotics during the previous 7 days were excluded. Sequential sampling was used; sample size: 1500 women. The ACON NG and CT duo test combo and the ACON individual test plates for NG and separately for CT were used. The QuickVue Chlamydia rapid test (RT) was also used. All of them were compared with nucleic acid amplification methods. The SD Bioline 3.0 and ACON test for syphilis were evaluated and compared with serological tests. Sensitivity and specificity were estimated. Results CT RTs had a sensitivity that ranged between 22.7% and 37.7% and specificity between 99.3% and 100%. Sensitivity for NG with ACON Duo was 12.5% and specificity 99.8%. Tests for syphilis had a sensitivity of 91.6-100% and a specificity of 99.7-97.8%. Conclusions The RTs studied are not useful for screening for NG at the point of care. In case of CT a recommendation about their use in routine care should be supported by a cost-effectiveness analysis. In screening populations at high risk of sexually transmitted infections or pregnant women, the RTs for syphilis should be used.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalSexually Transmitted Infections
Volume92
Issue number1
DOIs
StatePublished - Feb 1 2016

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Neisseria gonorrhoeae
Chlamydia trachomatis
Sexually Transmitted Diseases
Syphilis
Point-of-Care Systems
Urinary Tract Infections
Pregnant Women
Lower Urinary Tract Symptoms
Colombia
Chlamydia
Public Hospitals
Serologic Tests
Hysterectomy
Routine Diagnostic Tests
Sample Size
Nucleic Acids
Cost-Benefit Analysis
Cross-Sectional Studies
Anti-Bacterial Agents
Sensitivity and Specificity

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Nuñez-Forero, L., Moyano-Ariza, L., Gaitán-Duarte, H., Ángel-Müller, E., Ruiz-Parra, A., González, P., ... Tolosa, J. (2016). Diagnostic accuracy of rapid tests for sexually transmitted infections in symptomatic women. Sexually Transmitted Infections, 92(1), 24-28. https://doi.org/10.1136/sextrans-2014-051891

Diagnostic accuracy of rapid tests for sexually transmitted infections in symptomatic women. / Nuñez-Forero, Lilian; Moyano-Ariza, Luisa; Gaitán-Duarte, Hernando; Ángel-Müller, Edith; Ruiz-Parra, Ariel; González, Patricia; Rodríguez, Andrea; Tolosa, Jorge.

In: Sexually Transmitted Infections, Vol. 92, No. 1, 01.02.2016, p. 24-28.

Research output: Contribution to journalArticle

Nuñez-Forero, L, Moyano-Ariza, L, Gaitán-Duarte, H, Ángel-Müller, E, Ruiz-Parra, A, González, P, Rodríguez, A & Tolosa, J 2016, 'Diagnostic accuracy of rapid tests for sexually transmitted infections in symptomatic women', Sexually Transmitted Infections, vol. 92, no. 1, pp. 24-28. https://doi.org/10.1136/sextrans-2014-051891
Nuñez-Forero L, Moyano-Ariza L, Gaitán-Duarte H, Ángel-Müller E, Ruiz-Parra A, González P et al. Diagnostic accuracy of rapid tests for sexually transmitted infections in symptomatic women. Sexually Transmitted Infections. 2016 Feb 1;92(1):24-28. https://doi.org/10.1136/sextrans-2014-051891
Nuñez-Forero, Lilian ; Moyano-Ariza, Luisa ; Gaitán-Duarte, Hernando ; Ángel-Müller, Edith ; Ruiz-Parra, Ariel ; González, Patricia ; Rodríguez, Andrea ; Tolosa, Jorge. / Diagnostic accuracy of rapid tests for sexually transmitted infections in symptomatic women. In: Sexually Transmitted Infections. 2016 ; Vol. 92, No. 1. pp. 24-28.
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abstract = "Objective To determine the diagnostic accuracy of tests developed for use at the point of care for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and syphilis in women having symptoms of lower urinary tract infection. Methods Cross-sectional study involving sexually active 14-49-year-old women with lower urinary tract infection symptoms consulting during 2010 at a private health clinic and at two public hospitals in Bogot{\'a}, Colombia. Pregnant women, those with a previous hysterectomy or those who received antibiotics during the previous 7 days were excluded. Sequential sampling was used; sample size: 1500 women. The ACON NG and CT duo test combo and the ACON individual test plates for NG and separately for CT were used. The QuickVue Chlamydia rapid test (RT) was also used. All of them were compared with nucleic acid amplification methods. The SD Bioline 3.0 and ACON test for syphilis were evaluated and compared with serological tests. Sensitivity and specificity were estimated. Results CT RTs had a sensitivity that ranged between 22.7{\%} and 37.7{\%} and specificity between 99.3{\%} and 100{\%}. Sensitivity for NG with ACON Duo was 12.5{\%} and specificity 99.8{\%}. Tests for syphilis had a sensitivity of 91.6-100{\%} and a specificity of 99.7-97.8{\%}. Conclusions The RTs studied are not useful for screening for NG at the point of care. In case of CT a recommendation about their use in routine care should be supported by a cost-effectiveness analysis. In screening populations at high risk of sexually transmitted infections or pregnant women, the RTs for syphilis should be used.",
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