Diagnosis of second breast cancer events after initial diagnosis of early stage breast cancer

Diana S M Buist, Linn A. Abraham, William E. Barlow, Arun Krishnaraj, Regan C. Holdridge, Edward A. Sickles, Patricia (Patty) Carney, Karla Kerlikowske, Berta M. Geller

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

To examine whether there are any characteristics of women or their initial tumors that might be useful for tailoring surveillance recommendations to optimize outcomes. We followed 17,286 women for up to 5 years after an initial diagnosis of ductal carcinoma in situ (DCIS) or early stage (I/II) invasive breast cancer diagnosed between 1996 and 2006. We calculated rates per 1,000 women years of recurrences and second breast primaries relative to demographics, risk factors, and characteristics of initial diagnosis: stage, treatment, mode of initial diagnosis. Nearly 4% had a second breast cancer event (314 recurrences and 344 second breast primaries). Women who used adjuvant hormonal therapy or were ≥80 years had the lowest rates of second events. Factors associated with higher recurrence and second primary rates included: initial DCIS or stage IIB, estrogen/progesterone receptor-negative, younger women (

Original languageEnglish (US)
Pages (from-to)863-873
Number of pages11
JournalBreast Cancer Research and Treatment
Volume124
Issue number3
DOIs
StatePublished - Dec 2010

Fingerprint

Second Primary Neoplasms
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Recurrence
Breast
Progesterone Receptors
Estrogen Receptors
Demography
Therapeutics
Neoplasms

Keywords

  • Breast
  • Breast neoplasms
  • Carcinoma
  • Diagnostic imaging
  • Ductal
  • Local
  • Mammary
  • Mammography
  • Neoplasm recurrence
  • Neoplasms
  • Recurrence
  • Second primary
  • Ultrasonography

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Buist, D. S. M., Abraham, L. A., Barlow, W. E., Krishnaraj, A., Holdridge, R. C., Sickles, E. A., ... Geller, B. M. (2010). Diagnosis of second breast cancer events after initial diagnosis of early stage breast cancer. Breast Cancer Research and Treatment, 124(3), 863-873. https://doi.org/10.1007/s10549-010-1106-6

Diagnosis of second breast cancer events after initial diagnosis of early stage breast cancer. / Buist, Diana S M; Abraham, Linn A.; Barlow, William E.; Krishnaraj, Arun; Holdridge, Regan C.; Sickles, Edward A.; Carney, Patricia (Patty); Kerlikowske, Karla; Geller, Berta M.

In: Breast Cancer Research and Treatment, Vol. 124, No. 3, 12.2010, p. 863-873.

Research output: Contribution to journalArticle

Buist, DSM, Abraham, LA, Barlow, WE, Krishnaraj, A, Holdridge, RC, Sickles, EA, Carney, PP, Kerlikowske, K & Geller, BM 2010, 'Diagnosis of second breast cancer events after initial diagnosis of early stage breast cancer', Breast Cancer Research and Treatment, vol. 124, no. 3, pp. 863-873. https://doi.org/10.1007/s10549-010-1106-6
Buist, Diana S M ; Abraham, Linn A. ; Barlow, William E. ; Krishnaraj, Arun ; Holdridge, Regan C. ; Sickles, Edward A. ; Carney, Patricia (Patty) ; Kerlikowske, Karla ; Geller, Berta M. / Diagnosis of second breast cancer events after initial diagnosis of early stage breast cancer. In: Breast Cancer Research and Treatment. 2010 ; Vol. 124, No. 3. pp. 863-873.
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