Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity

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32 Scopus citations


Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.

Original languageEnglish (US)
Pages (from-to)1199-1202
Number of pages4
JournalKidney International
Issue number12
Publication statusPublished - Jun 2007


ASJC Scopus subject areas

  • Nephrology

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