Developmental toxicity of nicotine

A transdisciplinary synthesis and implications for emerging tobacco products

Lucinda J. England, Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, Dorothy Hatsukami, Frances Jensen, Denise Kandel, Bruce Lanphear, Frances Leslie, James R. Pauly, Jenae Neiderhiser, Mark Rubinstein, Theodore A. Slotkin, Eliot Spindel, Laura Stroud, Lauren Wakschlag

    Research output: Contribution to journalReview article

    46 Citations (Scopus)

    Abstract

    While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during adolescence is associated with deficits in working memory, attention, and auditory processing, as well as increased impulsivity and anxiety. Finally, recent animal studies suggest that nicotine has a priming effect that increases addiction liability for other drugs. The evidence that nicotine adversely affects fetal and adolescent development is sufficient to warrant public health measures to protect pregnant women, children, and adolescents from nicotine exposure.

    Original languageEnglish (US)
    Pages (from-to)176-189
    Number of pages14
    JournalNeuroscience and Biobehavioral Reviews
    Volume72
    DOIs
    StatePublished - Jan 1 2017

    Fingerprint

    Nicotine
    Tobacco Products
    Adolescent Development
    Impulsive Behavior
    Health
    Expert Testimony
    Fetal Development
    Short-Term Memory
    PubMed
    MEDLINE
    Tobacco
    Pregnant Women
    Anxiety
    Public Health
    Smoking
    Pregnancy
    Lung
    Research
    Pharmaceutical Preparations

    Keywords

    • Electronic nicotine delivery systems
    • Nicotine
    • Priority/special populations

    ASJC Scopus subject areas

    • Neuropsychology and Physiological Psychology
    • Cognitive Neuroscience
    • Behavioral Neuroscience

    Cite this

    Developmental toxicity of nicotine : A transdisciplinary synthesis and implications for emerging tobacco products. / England, Lucinda J.; Aagaard, Kjersti; Bloch, Michele; Conway, Kevin; Cosgrove, Kelly; Grana, Rachel; Gould, Thomas J.; Hatsukami, Dorothy; Jensen, Frances; Kandel, Denise; Lanphear, Bruce; Leslie, Frances; Pauly, James R.; Neiderhiser, Jenae; Rubinstein, Mark; Slotkin, Theodore A.; Spindel, Eliot; Stroud, Laura; Wakschlag, Lauren.

    In: Neuroscience and Biobehavioral Reviews, Vol. 72, 01.01.2017, p. 176-189.

    Research output: Contribution to journalReview article

    England, LJ, Aagaard, K, Bloch, M, Conway, K, Cosgrove, K, Grana, R, Gould, TJ, Hatsukami, D, Jensen, F, Kandel, D, Lanphear, B, Leslie, F, Pauly, JR, Neiderhiser, J, Rubinstein, M, Slotkin, TA, Spindel, E, Stroud, L & Wakschlag, L 2017, 'Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products', Neuroscience and Biobehavioral Reviews, vol. 72, pp. 176-189. https://doi.org/10.1016/j.neubiorev.2016.11.013
    England, Lucinda J. ; Aagaard, Kjersti ; Bloch, Michele ; Conway, Kevin ; Cosgrove, Kelly ; Grana, Rachel ; Gould, Thomas J. ; Hatsukami, Dorothy ; Jensen, Frances ; Kandel, Denise ; Lanphear, Bruce ; Leslie, Frances ; Pauly, James R. ; Neiderhiser, Jenae ; Rubinstein, Mark ; Slotkin, Theodore A. ; Spindel, Eliot ; Stroud, Laura ; Wakschlag, Lauren. / Developmental toxicity of nicotine : A transdisciplinary synthesis and implications for emerging tobacco products. In: Neuroscience and Biobehavioral Reviews. 2017 ; Vol. 72. pp. 176-189.
    @article{d772befe05cc47cbbf2dd9be3342948b,
    title = "Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products",
    abstract = "While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during adolescence is associated with deficits in working memory, attention, and auditory processing, as well as increased impulsivity and anxiety. Finally, recent animal studies suggest that nicotine has a priming effect that increases addiction liability for other drugs. The evidence that nicotine adversely affects fetal and adolescent development is sufficient to warrant public health measures to protect pregnant women, children, and adolescents from nicotine exposure.",
    keywords = "Electronic nicotine delivery systems, Nicotine, Priority/special populations",
    author = "England, {Lucinda J.} and Kjersti Aagaard and Michele Bloch and Kevin Conway and Kelly Cosgrove and Rachel Grana and Gould, {Thomas J.} and Dorothy Hatsukami and Frances Jensen and Denise Kandel and Bruce Lanphear and Frances Leslie and Pauly, {James R.} and Jenae Neiderhiser and Mark Rubinstein and Slotkin, {Theodore A.} and Eliot Spindel and Laura Stroud and Lauren Wakschlag",
    year = "2017",
    month = "1",
    day = "1",
    doi = "10.1016/j.neubiorev.2016.11.013",
    language = "English (US)",
    volume = "72",
    pages = "176--189",
    journal = "Neuroscience and Biobehavioral Reviews",
    issn = "0149-7634",
    publisher = "Elsevier Limited",

    }

    TY - JOUR

    T1 - Developmental toxicity of nicotine

    T2 - A transdisciplinary synthesis and implications for emerging tobacco products

    AU - England, Lucinda J.

    AU - Aagaard, Kjersti

    AU - Bloch, Michele

    AU - Conway, Kevin

    AU - Cosgrove, Kelly

    AU - Grana, Rachel

    AU - Gould, Thomas J.

    AU - Hatsukami, Dorothy

    AU - Jensen, Frances

    AU - Kandel, Denise

    AU - Lanphear, Bruce

    AU - Leslie, Frances

    AU - Pauly, James R.

    AU - Neiderhiser, Jenae

    AU - Rubinstein, Mark

    AU - Slotkin, Theodore A.

    AU - Spindel, Eliot

    AU - Stroud, Laura

    AU - Wakschlag, Lauren

    PY - 2017/1/1

    Y1 - 2017/1/1

    N2 - While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during adolescence is associated with deficits in working memory, attention, and auditory processing, as well as increased impulsivity and anxiety. Finally, recent animal studies suggest that nicotine has a priming effect that increases addiction liability for other drugs. The evidence that nicotine adversely affects fetal and adolescent development is sufficient to warrant public health measures to protect pregnant women, children, and adolescents from nicotine exposure.

    AB - While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during adolescence is associated with deficits in working memory, attention, and auditory processing, as well as increased impulsivity and anxiety. Finally, recent animal studies suggest that nicotine has a priming effect that increases addiction liability for other drugs. The evidence that nicotine adversely affects fetal and adolescent development is sufficient to warrant public health measures to protect pregnant women, children, and adolescents from nicotine exposure.

    KW - Electronic nicotine delivery systems

    KW - Nicotine

    KW - Priority/special populations

    UR - http://www.scopus.com/inward/record.url?scp=85002152485&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85002152485&partnerID=8YFLogxK

    U2 - 10.1016/j.neubiorev.2016.11.013

    DO - 10.1016/j.neubiorev.2016.11.013

    M3 - Review article

    VL - 72

    SP - 176

    EP - 189

    JO - Neuroscience and Biobehavioral Reviews

    JF - Neuroscience and Biobehavioral Reviews

    SN - 0149-7634

    ER -