TY - JOUR
T1 - Development of the labial pit organ glomerulus in the antennal lobe of the moth Manduca sexta
T2 - The role of afferent projections in the formation of identifiable olfactory glomeruli
AU - Kent, Karla S.
AU - Oland, Lynne A.
AU - Hildebrand, John G.
PY - 1999
Y1 - 1999
N2 - Iterated neuropil modules called glomeruli are characteristic of primary olfactory centers in both vertebrates and invertebrates. To gain insight into the developmental mechanisms underlying the formation of such structured, organized neuropil, we have examined the development of an identified glomerulus in the olfactory (antennal) lobe of the moth Manduca sexta. The labial pit organ glomerulus (LPOG) receives bilateral sensory projections from the labial pit organs in the labial palps of the mouthparts, while other glomeruli in the antennal lobe receive unilateral projections from the antenna. Here, we chronicle the development of the LPOG under normal and perturbed conditions. Our findings suggest that the sensory axons of the labial pit organ, like those of the antenna, induce and shape growth of interneuronal arborizations, but specific features of interneuronal arborizations such as the relative position of glomerular arborizations within the antennal lobe are independent of both classes of afferent innervation. Labial pit organ axons and antennal axons exhibit a high degree of specificity for their respective target regions, independent of the presence or absence of the other class of afferent axon or the route taken to the antennal lobe. Specification of glomerular position is intrinsic to the antennal lobe rather than a consequence of competition between afferent axons.
AB - Iterated neuropil modules called glomeruli are characteristic of primary olfactory centers in both vertebrates and invertebrates. To gain insight into the developmental mechanisms underlying the formation of such structured, organized neuropil, we have examined the development of an identified glomerulus in the olfactory (antennal) lobe of the moth Manduca sexta. The labial pit organ glomerulus (LPOG) receives bilateral sensory projections from the labial pit organs in the labial palps of the mouthparts, while other glomeruli in the antennal lobe receive unilateral projections from the antenna. Here, we chronicle the development of the LPOG under normal and perturbed conditions. Our findings suggest that the sensory axons of the labial pit organ, like those of the antenna, induce and shape growth of interneuronal arborizations, but specific features of interneuronal arborizations such as the relative position of glomerular arborizations within the antennal lobe are independent of both classes of afferent innervation. Labial pit organ axons and antennal axons exhibit a high degree of specificity for their respective target regions, independent of the presence or absence of the other class of afferent axon or the route taken to the antennal lobe. Specification of glomerular position is intrinsic to the antennal lobe rather than a consequence of competition between afferent axons.
KW - Cell-cell interactions
KW - Insect nervous system
KW - Interneurons
KW - Olfactory lobe
KW - Sensory neuropil
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U2 - 10.1002/(SICI)1097-4695(199907)40:1<28::AID-NEU3>3.0.CO;2-E
DO - 10.1002/(SICI)1097-4695(199907)40:1<28::AID-NEU3>3.0.CO;2-E
M3 - Article
C2 - 10398069
AN - SCOPUS:0033015198
SN - 0022-3034
VL - 40
SP - 28
EP - 44
JO - Journal of Neurobiology
JF - Journal of Neurobiology
IS - 1
ER -