Development of a reinforced porcine elastin composite vascular scaffold

Monica T. Hinds, Rebecca C. Rowe, Zhen Ren, Jeffrey Teach, Ping Cheng Wu, Sean J. Kirkpatrick, Kathryn D. Breneman, Kenton W. Gregory, David W. Courtman

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Elastin, a principal structural component of native arteries, has distinct biological and mechanical advantages when used as a biomaterial; however, its low ultimate tensile strength has limited its use as an arterial conduit. We have developed a scaffold, consisting of a purified elastin tubular conduit strengthened with fibrin bonded layers of acellular small intestinal submucosa (aSIS) for potential use as a small diameter vascular graft. The addition of aSIS increased the ultimate tensile strength of the elastin conduits nine-fold. Burst pressures for the elastin composite vascular scaffold (1396 ± 309 mmHg) were significantly higher than pure elastin conduits (162 ± 36 mmHg) and comparable to native saphenous veins. The average suture pullout strength of the elastin composite vascular scaffolds was 14.612 ± 3.677 N, significantly higher than the pure elastin conduit (0.402 ± 0.098 N), but comparable to native porcine carotid arteries (13.994 ± 4.344 N). Cyclic circumferential strain testing indicated that the composite scaffolds were capable of withstanding physiological loading conditions for at least 83 h. Implantation of the elastin composites as carotid interposition grafts in swine demonstrated its superiority to clinically acceptable ePTFE with significantly longer average patency times of 5.23 h compared to 4.15 h. We have developed a biologically based elastin scaffold with suitable mechanical properties and low thrombogenicity for in vivo implantation, and with the potential for cellular repopulation and host integration reestablishing an appropriate elastic artery.

Original languageEnglish (US)
Pages (from-to)458-469
Number of pages12
JournalJournal of Biomedical Materials Research - Part A
Issue number3
StatePublished - Jun 1 2006


  • Elastin
  • Scaffold
  • Vascular grafts

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys


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