Development and validation of a deep learning algorithm for distinguishing the nonperfusion area from signal reduction artifacts on OCT angiography

Yukun Guo, Tristan T. Hormel, Honglian Xiong, Bingjie Wang, Acner Camino, Jie Wang, David Huang, Thomas Hwang, Jia Yali

Research output: Contribution to journalArticle

2 Scopus citations


The capillary nonperfusion area (NPA) is a key quantifiable biomarker in the evaluation of diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). However, signal reduction artifacts caused by vitreous floaters, pupil vignetting, or defocus present significant obstacles to accurate quantification. We have developed a convolutional neural network, MEDnet-V2, to distinguish NPA from signal reduction artifacts in 6×6 mm2 OCTA. The network achieves strong specificity and sensitivity for NPA detection across a wide range of DR severity and scan quality.

Original languageEnglish (US)
Pages (from-to)3257-3268
Number of pages12
JournalBiomedical Optics Express
Issue number7
Publication statusPublished - Jul 1 2019


ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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