Developing dementia prevention trials: Baseline report of the home-based assessment study

Mary Sano, Susan Egelko, Michael Donohue, Steven Ferris, Jeffrey Kaye, Tamara L. Hayes, James C. Mundt, Chung Kai Sun, Silvia Paparello, Paul S. Aisen

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

This report describes the baseline experience of the multicenter, Home-Based Assessment study, designed to develop methods for dementia prevention trials using novel technologies for test administration and data collection. Nondemented individuals of 75 years of age or more were recruited and evaluated in-person using established clinical trial outcomes of cognition and function, and randomized to one of 3 assessment methodologies: (1) mail-in questionnaire/live telephone interviews [mail-in/phone (MIP)]; (2) automated telephone with interactive voice recognition; and (3) internet-based computer Kiosk. Brief versions of cognitive and noncognitive outcomes were adapted to each methodology and administered at baseline and repeatedly over a 4-year period. "Efficiency" measures assessed the time from screening to baseline, and staff time required for each methodology. A total of 713 individuals signed consent and were screened; 640 met eligibility and were randomized to one of 3 assessment arms; and 581 completed baseline. Dropout, time from screening to baseline, and total staff time were highest among those assigned to internet-based computer Kiosk. However, efficiency measures were driven by nonrecurring start-up activities suggesting that differences may be mitigated over a long trial. Performance among Home-Based Assessment instruments collected through different technologies will be compared with established outcomes over this 4-year study.

Original languageEnglish (US)
Pages (from-to)356-362
Number of pages7
JournalAlzheimer Disease and Associated Disorders
Volume27
Issue number4
DOIs
StatePublished - Oct 1 2013

Keywords

  • Alzheimer disease
  • clinical trials
  • in-home assessment
  • prevention studies

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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    Sano, M., Egelko, S., Donohue, M., Ferris, S., Kaye, J., Hayes, T. L., Mundt, J. C., Sun, C. K., Paparello, S., & Aisen, P. S. (2013). Developing dementia prevention trials: Baseline report of the home-based assessment study. Alzheimer Disease and Associated Disorders, 27(4), 356-362. https://doi.org/10.1097/WAD.0b013e3182769c05