Determining organ doses from CT with direct measurements in postmortem subjects: Part 2-correlations with patientspecific parameters

Lindsay Sinclair, Thomas M. Griglock, Anna Mench, Rebecca Lamoureux, Brian Cormack, Sharatchandra Bidari, Lynn Rill, Manuel Arreola

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Purpose: To generate empirical sets of equations that can be used to calculate patient-specific organ doses resulting from a group of computed tomographic (CT) studies by using data from direct dose measurements performed within a human body. Materials and Methods: Organ dose measurements were obtained in eight postmortem female subjects. A chest-abdomen-pelvis protocol was used for this study. The relationships among measured organ doses, body mass index, effective diameter (Deff), and volume CT dose index (CTDIvol) were investigated. Organ dose equations were developed by means of linear regression from organ dose data, with CTDIvol and Deff as variables, by using Pearson correlation coefficients and P values to determine correlation strength of fit. Measured organ doses were compared with corresponding size-specific dose estimates (SSDEs). Results: The central-section Deff presented similar correlations with organ doses to those from Deff measured at specific organ locations. The strongest correlations were observed between the central-section Deff and CTDIvol-normalized organ doses (R2: 0.478-0.941). The average of measured organ doses for each subject resulted in an average difference of only 5% from SSDE-calculated doses; however, individual organ doses differed from +31% to 261% from the calculated SSDE. Conclusion: The organ dose equations developed represent a method for organ dose estimation from direct organ dose measurements that can estimate organ doses more accurately than the calculated SSDE, which provides a less-specific patient dose estimate.

Original languageEnglish (US)
Pages (from-to)471-476
Number of pages6
JournalRADIOLOGY
Volume277
Issue number2
DOIs
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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