Determination and distribution of left ventricular size as measured by noncontrast CT in the Multi-Ethnic Study of Atherosclerosis

Waqas T. Qureshi, Khurram Nasir, Yalcin Hacioglu, Christopher Sibley, Mohit Gupta, Juan J. Rivera, Roger Blumenthal, Ronit Katz, Matthew J. Budoff

Research output: Contribution to journalArticle

Abstract

Background: Left ventricular (LV) volume and mass have prognostic relevance. Overall size of the left ventricle as it appears in noncontrast CT is a composite of the ventricular volume and myocardial mass. We describe a method to estimate the LV size using a single cross-section in noncontrast CT and determined normal ranges on the basis of a large population cohort. Methods: The Multi-Ethnic Study of Atherosclerosis with 6814 participants from 4 ethnicities who were free of known cardiovascular disease and enrolled between 2000 and 2002 form the basis of our analysis. LV size was calculated from a single cross-sectional slice obtained by either nonenhanced electron beam or multidetector CT. LV size was adjusted to body surface area to obtain the LV size index, which was adjusted for age, sex, race or ethnicity, hypertension, hyperlipidemia, and diabetes. Results: There were significant differences in LV size index by race which were further influenced by age and sex. Higher values were noted in men in all ethnic groups across all age groups. Similarly, LV size index uniformly decreased with age across all ethnic and sex categories. Caucasians had the lowest and African Americans had the highest LV size index across all age and sex categories. In multivariate regression analyses adjusted for age, sex, race or ethnicity, hypertension, hyperlipidemia, smoking, and diabetes mellitus, the significant differences were noted between male vs female (median difference, 17.5 cc/m2; P <.001), ethnic groups (Caucasian, reference group; Asian, 3.7 cc/m2; African American, 8.3 cc/m2; and Hispanic, 5.6 cc/m2; P <.001), and age groups (45-54years, reference group; 55-64years,-5.2 cc/m2; 65-74years,-11.4 cc/m2; and 74-84years,-12.5 cc/m2). Conclusions: This study provides normative values for LV size as determined from a single, nonenhanced CT cross-section and indexed to body surface area, and it demonstrates that the LV size index varies by age, sex, and ethnic background.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalJournal of Cardiovascular Computed Tomography
Volume9
Issue number2
DOIs
StatePublished - 2015

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Atherosclerosis
Body Surface Area
Hyperlipidemias
Ethnic Groups
African Americans
Age Groups
Hypertension
Hispanic Americans
Heart Ventricles
Diabetes Mellitus
Reference Values
Cardiovascular Diseases
Multivariate Analysis
Smoking
Regression Analysis
Electrons
Population

Keywords

  • CT
  • Ethnicity
  • Left ventricular size
  • Noncontrast CT
  • Normative values
  • Reference measures

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Determination and distribution of left ventricular size as measured by noncontrast CT in the Multi-Ethnic Study of Atherosclerosis. / Qureshi, Waqas T.; Nasir, Khurram; Hacioglu, Yalcin; Sibley, Christopher; Gupta, Mohit; Rivera, Juan J.; Blumenthal, Roger; Katz, Ronit; Budoff, Matthew J.

In: Journal of Cardiovascular Computed Tomography, Vol. 9, No. 2, 2015, p. 113-119.

Research output: Contribution to journalArticle

Qureshi, WT, Nasir, K, Hacioglu, Y, Sibley, C, Gupta, M, Rivera, JJ, Blumenthal, R, Katz, R & Budoff, MJ 2015, 'Determination and distribution of left ventricular size as measured by noncontrast CT in the Multi-Ethnic Study of Atherosclerosis', Journal of Cardiovascular Computed Tomography, vol. 9, no. 2, pp. 113-119. https://doi.org/10.1016/j.jcct.2015.01.001
Qureshi, Waqas T. ; Nasir, Khurram ; Hacioglu, Yalcin ; Sibley, Christopher ; Gupta, Mohit ; Rivera, Juan J. ; Blumenthal, Roger ; Katz, Ronit ; Budoff, Matthew J. / Determination and distribution of left ventricular size as measured by noncontrast CT in the Multi-Ethnic Study of Atherosclerosis. In: Journal of Cardiovascular Computed Tomography. 2015 ; Vol. 9, No. 2. pp. 113-119.
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T1 - Determination and distribution of left ventricular size as measured by noncontrast CT in the Multi-Ethnic Study of Atherosclerosis

AU - Qureshi, Waqas T.

AU - Nasir, Khurram

AU - Hacioglu, Yalcin

AU - Sibley, Christopher

AU - Gupta, Mohit

AU - Rivera, Juan J.

AU - Blumenthal, Roger

AU - Katz, Ronit

AU - Budoff, Matthew J.

PY - 2015

Y1 - 2015

N2 - Background: Left ventricular (LV) volume and mass have prognostic relevance. Overall size of the left ventricle as it appears in noncontrast CT is a composite of the ventricular volume and myocardial mass. We describe a method to estimate the LV size using a single cross-section in noncontrast CT and determined normal ranges on the basis of a large population cohort. Methods: The Multi-Ethnic Study of Atherosclerosis with 6814 participants from 4 ethnicities who were free of known cardiovascular disease and enrolled between 2000 and 2002 form the basis of our analysis. LV size was calculated from a single cross-sectional slice obtained by either nonenhanced electron beam or multidetector CT. LV size was adjusted to body surface area to obtain the LV size index, which was adjusted for age, sex, race or ethnicity, hypertension, hyperlipidemia, and diabetes. Results: There were significant differences in LV size index by race which were further influenced by age and sex. Higher values were noted in men in all ethnic groups across all age groups. Similarly, LV size index uniformly decreased with age across all ethnic and sex categories. Caucasians had the lowest and African Americans had the highest LV size index across all age and sex categories. In multivariate regression analyses adjusted for age, sex, race or ethnicity, hypertension, hyperlipidemia, smoking, and diabetes mellitus, the significant differences were noted between male vs female (median difference, 17.5 cc/m2; P <.001), ethnic groups (Caucasian, reference group; Asian, 3.7 cc/m2; African American, 8.3 cc/m2; and Hispanic, 5.6 cc/m2; P <.001), and age groups (45-54years, reference group; 55-64years,-5.2 cc/m2; 65-74years,-11.4 cc/m2; and 74-84years,-12.5 cc/m2). Conclusions: This study provides normative values for LV size as determined from a single, nonenhanced CT cross-section and indexed to body surface area, and it demonstrates that the LV size index varies by age, sex, and ethnic background.

AB - Background: Left ventricular (LV) volume and mass have prognostic relevance. Overall size of the left ventricle as it appears in noncontrast CT is a composite of the ventricular volume and myocardial mass. We describe a method to estimate the LV size using a single cross-section in noncontrast CT and determined normal ranges on the basis of a large population cohort. Methods: The Multi-Ethnic Study of Atherosclerosis with 6814 participants from 4 ethnicities who were free of known cardiovascular disease and enrolled between 2000 and 2002 form the basis of our analysis. LV size was calculated from a single cross-sectional slice obtained by either nonenhanced electron beam or multidetector CT. LV size was adjusted to body surface area to obtain the LV size index, which was adjusted for age, sex, race or ethnicity, hypertension, hyperlipidemia, and diabetes. Results: There were significant differences in LV size index by race which were further influenced by age and sex. Higher values were noted in men in all ethnic groups across all age groups. Similarly, LV size index uniformly decreased with age across all ethnic and sex categories. Caucasians had the lowest and African Americans had the highest LV size index across all age and sex categories. In multivariate regression analyses adjusted for age, sex, race or ethnicity, hypertension, hyperlipidemia, smoking, and diabetes mellitus, the significant differences were noted between male vs female (median difference, 17.5 cc/m2; P <.001), ethnic groups (Caucasian, reference group; Asian, 3.7 cc/m2; African American, 8.3 cc/m2; and Hispanic, 5.6 cc/m2; P <.001), and age groups (45-54years, reference group; 55-64years,-5.2 cc/m2; 65-74years,-11.4 cc/m2; and 74-84years,-12.5 cc/m2). Conclusions: This study provides normative values for LV size as determined from a single, nonenhanced CT cross-section and indexed to body surface area, and it demonstrates that the LV size index varies by age, sex, and ethnic background.

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KW - Ethnicity

KW - Left ventricular size

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KW - Normative values

KW - Reference measures

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