Depth of photothermal conversion of gold nanorods embedded in a tissue-like phantom

Candice L. Didychuk, Pinhas Ephrat, Astrid Chamson-Reig, Steven Jacques, Jeffrey J L Carson

Research output: Contribution to journalArticle

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Abstract

Gold nanorod (AuNR)-assisted photothermal therapy has emerged as a viable method for selective killing of cancer cells and shows promise for tumor destruction in vivo. This study examined the distribution of AuNR conversion expected to occur during photothermal therapy in vivo. Tissue-like phantoms were prepared with polyethylene glycol AuNRs distributed homogeneously at a concentration representative of a systemic injection. Phantoms were illuminated with a nanosecond pulsed laser (800 nm) at a variety of combinations of pulse energy (12-120 mJ) and pulse count (1-1000). Operating at the American National Standards Institute safety limit for human skin exposure (30 mJ cm -2), a diameter of 13 mm and a depth of 7.6 mm of AuNR conversion were observed in the gel phantoms after 1000 laser pulses (100 s exposure). Significant AuNR conversion was measured to a depth of 6 mm after only 100 pulses. Comparison of the measured AuNR conversion distribution with Monte Carlo simulation suggested that the fluence threshold for AuNR conversion estimated from phantom measurements was in the range of 20-43 mJ cm-2. The results suggest that AuNR-assisted photothermal therapy will be effective for tumors within 10 mm of the illuminated tissue surface.

Original languageEnglish (US)
Article number195102
JournalNanotechnology
Volume20
Issue number19
DOIs
StatePublished - 2009

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Nanorods
Gold
Tumors
Tissue
Pulsed lasers
Polyethylene glycols
Laser pulses
Skin
Gels
Cells
Monte Carlo simulation

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Science(all)

Cite this

Didychuk, C. L., Ephrat, P., Chamson-Reig, A., Jacques, S., & Carson, J. J. L. (2009). Depth of photothermal conversion of gold nanorods embedded in a tissue-like phantom. Nanotechnology, 20(19), [195102]. https://doi.org/10.1088/0957-4484/20/19/195102

Depth of photothermal conversion of gold nanorods embedded in a tissue-like phantom. / Didychuk, Candice L.; Ephrat, Pinhas; Chamson-Reig, Astrid; Jacques, Steven; Carson, Jeffrey J L.

In: Nanotechnology, Vol. 20, No. 19, 195102, 2009.

Research output: Contribution to journalArticle

Didychuk, CL, Ephrat, P, Chamson-Reig, A, Jacques, S & Carson, JJL 2009, 'Depth of photothermal conversion of gold nanorods embedded in a tissue-like phantom', Nanotechnology, vol. 20, no. 19, 195102. https://doi.org/10.1088/0957-4484/20/19/195102
Didychuk, Candice L. ; Ephrat, Pinhas ; Chamson-Reig, Astrid ; Jacques, Steven ; Carson, Jeffrey J L. / Depth of photothermal conversion of gold nanorods embedded in a tissue-like phantom. In: Nanotechnology. 2009 ; Vol. 20, No. 19.
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