Depressive symptoms in adolescents: Associations with white matter volume and marijuana use

Krista Lisdahl Medina, Bonnie Nagel, Ann Park, Tim Mcqueeny, Susan F. Tapert

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Bakground: Depressed mood has been associated with decreased white matter and reduced hippocampal volumes. However, the relationship between brain structure and mood may be unique among adolescents who use marijuana heavily. The goal of this study was to examine the relationship between white matter and hippocampal volumes and depressive symptoms among adolescent marijuana users and controls. Methods: Data were collected from marijuana users (n=16) and demographically similar controls (n=16) aged 16-18. Extensive exclusionary criteria included psychiatric and neurologic disorders, including major depression. Substance use, mood, and anatomical measures were collected after 28days of monitored abstinence. Results: Marijuana (MJ) users demonstrated more depressive symptoms than controls (p

Original languageEnglish (US)
Pages (from-to)592-600
Number of pages9
JournalJournal of Child Psychology and Psychiatry and Allied Disciplines
Volume48
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

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Cannabis
Depression
Nervous System Diseases
Psychiatry
White Matter
Brain

Keywords

  • Adolescence
  • Brain imaging
  • Cannabis
  • Depression
  • Hippocampus
  • Marijuana abuse
  • MRI
  • Neuroimaging
  • White matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Depressive symptoms in adolescents : Associations with white matter volume and marijuana use. / Medina, Krista Lisdahl; Nagel, Bonnie; Park, Ann; Mcqueeny, Tim; Tapert, Susan F.

In: Journal of Child Psychology and Psychiatry and Allied Disciplines, Vol. 48, No. 6, 06.2007, p. 592-600.

Research output: Contribution to journalArticle

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