Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease

Medicine & Life Sciences

• 2'-deoxyadenosine 100%
• T-Cell Lymphoma 77%
• Severe combined immunodeficiency due to adenosine deaminase deficiency 34%
• Deoxycytidine 32%
• Deoxycytidine Kinase 17%
• Adenosine Kinase 16%
• Adenosine Deaminase 14%
• triphosphoric acid 13%
• 2'-deoxyadenosine triphosphate 10%
• Adenosine Deaminase Inhibitors 8%
• Purine-Nucleoside Phosphorylase 8%
• Cell Culture Techniques 8%
• Ribonucleotide Reductases 7%
• purine 6%

Chemical Compounds

• Adenosine 63%
• Pharmacological Metabolism 51%
• EC 3.5.4.4 (Adenosine Deaminase) Inhibitor 14%
• Purine Nucleoside 10%
• Ribonucleotide 10%
• Lethal 9%
• Purine 8%
• Kinetics Type 7%
• Toxic 6%
• Simulation 5%