Dentine as a bioactive extracellular matrix

A. J. Smith, B. A. Scheven, Y. Takahashi, Jack Ferracane, R. M. Shelton, P. R. Cooper

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine-pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell-matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.

Original languageEnglish (US)
Pages (from-to)109-121
Number of pages13
JournalArchives of Oral Biology
Volume57
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Dentin
Extracellular Matrix
Tooth Components
Bone Matrix
Cell Communication
Connective Tissue
Inflammation
Wounds and Injuries
Infection
Therapeutics

Keywords

  • Bioactive
  • Dentine
  • Extracellular matrix
  • Inflammation
  • Regeneration

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Cell Biology
  • Dentistry(all)

Cite this

Smith, A. J., Scheven, B. A., Takahashi, Y., Ferracane, J., Shelton, R. M., & Cooper, P. R. (2012). Dentine as a bioactive extracellular matrix. Archives of Oral Biology, 57(2), 109-121. https://doi.org/10.1016/j.archoralbio.2011.07.008

Dentine as a bioactive extracellular matrix. / Smith, A. J.; Scheven, B. A.; Takahashi, Y.; Ferracane, Jack; Shelton, R. M.; Cooper, P. R.

In: Archives of Oral Biology, Vol. 57, No. 2, 02.2012, p. 109-121.

Research output: Contribution to journalArticle

Smith, AJ, Scheven, BA, Takahashi, Y, Ferracane, J, Shelton, RM & Cooper, PR 2012, 'Dentine as a bioactive extracellular matrix', Archives of Oral Biology, vol. 57, no. 2, pp. 109-121. https://doi.org/10.1016/j.archoralbio.2011.07.008
Smith AJ, Scheven BA, Takahashi Y, Ferracane J, Shelton RM, Cooper PR. Dentine as a bioactive extracellular matrix. Archives of Oral Biology. 2012 Feb;57(2):109-121. https://doi.org/10.1016/j.archoralbio.2011.07.008
Smith, A. J. ; Scheven, B. A. ; Takahashi, Y. ; Ferracane, Jack ; Shelton, R. M. ; Cooper, P. R. / Dentine as a bioactive extracellular matrix. In: Archives of Oral Biology. 2012 ; Vol. 57, No. 2. pp. 109-121.
@article{ccff5185d87d4ff79e1868355415d8a4,
title = "Dentine as a bioactive extracellular matrix",
abstract = "As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine-pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell-matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.",
keywords = "Bioactive, Dentine, Extracellular matrix, Inflammation, Regeneration",
author = "Smith, {A. J.} and Scheven, {B. A.} and Y. Takahashi and Jack Ferracane and Shelton, {R. M.} and Cooper, {P. R.}",
year = "2012",
month = "2",
doi = "10.1016/j.archoralbio.2011.07.008",
language = "English (US)",
volume = "57",
pages = "109--121",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Dentine as a bioactive extracellular matrix

AU - Smith, A. J.

AU - Scheven, B. A.

AU - Takahashi, Y.

AU - Ferracane, Jack

AU - Shelton, R. M.

AU - Cooper, P. R.

PY - 2012/2

Y1 - 2012/2

N2 - As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine-pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell-matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.

AB - As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine-pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell-matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.

KW - Bioactive

KW - Dentine

KW - Extracellular matrix

KW - Inflammation

KW - Regeneration

UR - http://www.scopus.com/inward/record.url?scp=84856084995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856084995&partnerID=8YFLogxK

U2 - 10.1016/j.archoralbio.2011.07.008

DO - 10.1016/j.archoralbio.2011.07.008

M3 - Article

VL - 57

SP - 109

EP - 121

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - 2

ER -