TY - JOUR
T1 - Denervation effects on newt limb regeneration
T2 - DNA polymerase activity in vitro
AU - Dresden, Marc H.
AU - Moses, Robb E.
N1 - Funding Information:
The technical assistance of Mrs. Dora Payne and Mr. David Bowersock is gratefully acknowledged. This work was supported by a contract from the U.S. Atomic Energy Commission (M.H.D.) and grants from the National Science Foundation (M.H.D.) and the National Institutes of Health (R.E.M.). R.E.M. holds a Career Development Award (GM-70,314).
PY - 1973/10
Y1 - 1973/10
N2 - DNA polymerase activity in extracts of newt (Triturus viridescens) tissues was assayed in an effort to characterize the effect of nerve resection on the regeneration of amputated limbs. Regenerating limbs display 5-20 times more polymerase activity than nonregenerating limbs. Denervation of partially regenerated limbs, which completely prevents further regeneration in vivo does not, however, affect DNA polymerase activity assayed in vitro. These results suggest that while DNA polymerase activity is responsive to the stimulus of regeneration, denervation effects are probably not directly exerted on this enzyme activity.
AB - DNA polymerase activity in extracts of newt (Triturus viridescens) tissues was assayed in an effort to characterize the effect of nerve resection on the regeneration of amputated limbs. Regenerating limbs display 5-20 times more polymerase activity than nonregenerating limbs. Denervation of partially regenerated limbs, which completely prevents further regeneration in vivo does not, however, affect DNA polymerase activity assayed in vitro. These results suggest that while DNA polymerase activity is responsive to the stimulus of regeneration, denervation effects are probably not directly exerted on this enzyme activity.
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U2 - 10.1016/0012-1606(73)90363-1
DO - 10.1016/0012-1606(73)90363-1
M3 - Article
C2 - 4789447
AN - SCOPUS:0015840701
VL - 34
SP - 346
EP - 350
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -