Abstract
DNA polymerase activity in extracts of newt (Triturus viridescens) tissues was assayed in an effort to characterize the effect of nerve resection on the regeneration of amputated limbs. Regenerating limbs display 5-20 times more polymerase activity than nonregenerating limbs. Denervation of partially regenerated limbs, which completely prevents further regeneration in vivo does not, however, affect DNA polymerase activity assayed in vitro. These results suggest that while DNA polymerase activity is responsive to the stimulus of regeneration, denervation effects are probably not directly exerted on this enzyme activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 346-350 |
| Number of pages | 5 |
| Journal | Developmental Biology |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1973 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Developmental Biology
Cite this
Denervation effects on newt limb regeneration : DNA polymerase activity in vitro. / Dresden, Marc H.; Moses, Robb.
In: Developmental Biology, Vol. 34, No. 2, 1973, p. 346-350.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Denervation effects on newt limb regeneration
T2 - DNA polymerase activity in vitro
AU - Dresden, Marc H.
AU - Moses, Robb
PY - 1973
Y1 - 1973
N2 - DNA polymerase activity in extracts of newt (Triturus viridescens) tissues was assayed in an effort to characterize the effect of nerve resection on the regeneration of amputated limbs. Regenerating limbs display 5-20 times more polymerase activity than nonregenerating limbs. Denervation of partially regenerated limbs, which completely prevents further regeneration in vivo does not, however, affect DNA polymerase activity assayed in vitro. These results suggest that while DNA polymerase activity is responsive to the stimulus of regeneration, denervation effects are probably not directly exerted on this enzyme activity.
AB - DNA polymerase activity in extracts of newt (Triturus viridescens) tissues was assayed in an effort to characterize the effect of nerve resection on the regeneration of amputated limbs. Regenerating limbs display 5-20 times more polymerase activity than nonregenerating limbs. Denervation of partially regenerated limbs, which completely prevents further regeneration in vivo does not, however, affect DNA polymerase activity assayed in vitro. These results suggest that while DNA polymerase activity is responsive to the stimulus of regeneration, denervation effects are probably not directly exerted on this enzyme activity.
UR - http://www.scopus.com/inward/record.url?scp=0015840701&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015840701&partnerID=8YFLogxK
U2 - 10.1016/0012-1606(73)90363-1
DO - 10.1016/0012-1606(73)90363-1
M3 - Article
VL - 34
SP - 346
EP - 350
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -