Dehydroepiandrosterone and age-related cognitive decline

Krystina G. Sorwell, Henryk Urbanski

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    In humans the circulating concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) decrease markedly during aging, and have been implicated in age-associated cognitive decline. This has led to the hypothesis that DHEA supplementation during aging may improve memory. In rodents, a cognitive anti-aging effect of DHEA and DHEAS has been observed but it is unclear whether this effect is mediated indirectly through conversion of these steroids to estradiol. Moreover, despite the demonstration of correlations between endogenous DHEA concentrations and cognitive ability in certain human patient populations, such correlations have yet to be convincingly demonstrated during normal human aging. This review highlights important differences between rodents and primates in terms of their circulating DHEA and DHEAS concentrations, and suggests that age-related changes within the human DHEA metabolic pathway may contribute to the relative inefficacy of DHEA replacement therapies in humans. The review also highlights the value of using nonhuman primates as a pragmatic animal model for testing the therapeutic potential of DHEA for age-associate cognitive decline in humans.

    Original languageEnglish (US)
    Pages (from-to)61-67
    Number of pages7
    JournalAge
    Volume32
    Issue number1
    DOIs
    StatePublished - Mar 2010

    Fingerprint

    Dehydroepiandrosterone
    Dehydroepiandrosterone Sulfate
    Primates
    Rodentia
    Aptitude
    Metabolic Networks and Pathways
    Cognitive Dysfunction
    Estradiol
    Animal Models
    Steroids
    Therapeutics
    Population

    Keywords

    • Cognitive decline
    • Dehydroepiandrosterone
    • Intracrinology
    • Neurosteroidogenesis

    ASJC Scopus subject areas

    • Aging
    • Geriatrics and Gerontology

    Cite this

    Dehydroepiandrosterone and age-related cognitive decline. / Sorwell, Krystina G.; Urbanski, Henryk.

    In: Age, Vol. 32, No. 1, 03.2010, p. 61-67.

    Research output: Contribution to journalArticle

    Sorwell, Krystina G. ; Urbanski, Henryk. / Dehydroepiandrosterone and age-related cognitive decline. In: Age. 2010 ; Vol. 32, No. 1. pp. 61-67.
    @article{dbb378ef296c44a0a52287205ba1d825,
    title = "Dehydroepiandrosterone and age-related cognitive decline",
    abstract = "In humans the circulating concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) decrease markedly during aging, and have been implicated in age-associated cognitive decline. This has led to the hypothesis that DHEA supplementation during aging may improve memory. In rodents, a cognitive anti-aging effect of DHEA and DHEAS has been observed but it is unclear whether this effect is mediated indirectly through conversion of these steroids to estradiol. Moreover, despite the demonstration of correlations between endogenous DHEA concentrations and cognitive ability in certain human patient populations, such correlations have yet to be convincingly demonstrated during normal human aging. This review highlights important differences between rodents and primates in terms of their circulating DHEA and DHEAS concentrations, and suggests that age-related changes within the human DHEA metabolic pathway may contribute to the relative inefficacy of DHEA replacement therapies in humans. The review also highlights the value of using nonhuman primates as a pragmatic animal model for testing the therapeutic potential of DHEA for age-associate cognitive decline in humans.",
    keywords = "Cognitive decline, Dehydroepiandrosterone, Intracrinology, Neurosteroidogenesis",
    author = "Sorwell, {Krystina G.} and Henryk Urbanski",
    year = "2010",
    month = "3",
    doi = "10.1007/s11357-009-9113-4",
    language = "English (US)",
    volume = "32",
    pages = "61--67",
    journal = "GeroScience",
    issn = "2509-2715",
    publisher = "Springer International Publishing AG",
    number = "1",

    }

    TY - JOUR

    T1 - Dehydroepiandrosterone and age-related cognitive decline

    AU - Sorwell, Krystina G.

    AU - Urbanski, Henryk

    PY - 2010/3

    Y1 - 2010/3

    N2 - In humans the circulating concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) decrease markedly during aging, and have been implicated in age-associated cognitive decline. This has led to the hypothesis that DHEA supplementation during aging may improve memory. In rodents, a cognitive anti-aging effect of DHEA and DHEAS has been observed but it is unclear whether this effect is mediated indirectly through conversion of these steroids to estradiol. Moreover, despite the demonstration of correlations between endogenous DHEA concentrations and cognitive ability in certain human patient populations, such correlations have yet to be convincingly demonstrated during normal human aging. This review highlights important differences between rodents and primates in terms of their circulating DHEA and DHEAS concentrations, and suggests that age-related changes within the human DHEA metabolic pathway may contribute to the relative inefficacy of DHEA replacement therapies in humans. The review also highlights the value of using nonhuman primates as a pragmatic animal model for testing the therapeutic potential of DHEA for age-associate cognitive decline in humans.

    AB - In humans the circulating concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) decrease markedly during aging, and have been implicated in age-associated cognitive decline. This has led to the hypothesis that DHEA supplementation during aging may improve memory. In rodents, a cognitive anti-aging effect of DHEA and DHEAS has been observed but it is unclear whether this effect is mediated indirectly through conversion of these steroids to estradiol. Moreover, despite the demonstration of correlations between endogenous DHEA concentrations and cognitive ability in certain human patient populations, such correlations have yet to be convincingly demonstrated during normal human aging. This review highlights important differences between rodents and primates in terms of their circulating DHEA and DHEAS concentrations, and suggests that age-related changes within the human DHEA metabolic pathway may contribute to the relative inefficacy of DHEA replacement therapies in humans. The review also highlights the value of using nonhuman primates as a pragmatic animal model for testing the therapeutic potential of DHEA for age-associate cognitive decline in humans.

    KW - Cognitive decline

    KW - Dehydroepiandrosterone

    KW - Intracrinology

    KW - Neurosteroidogenesis

    UR - http://www.scopus.com/inward/record.url?scp=77949424756&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=77949424756&partnerID=8YFLogxK

    U2 - 10.1007/s11357-009-9113-4

    DO - 10.1007/s11357-009-9113-4

    M3 - Article

    VL - 32

    SP - 61

    EP - 67

    JO - GeroScience

    JF - GeroScience

    SN - 2509-2715

    IS - 1

    ER -