Defecatory function in Parkinson's disease

Response to apomorphine

L. L. Edwards, E. M M Quigley, R. K. Harned, Ruth Hofman, Ronald Pfeiffer

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

We evaluated the effects of the dopaminergic agent apomorphine on defecation and anorectal function in patients with Parkinson's disease (PD). A gastrointestinal symptom survey, extrapyramidal assessment, defecating proctogram, and anorectal manometric study were performed in 8 subjects with PD. Basal studies showing abnormalities were repeated following apomorphine administration. Prior defecographic abnormalities were normalized following apomorphine injection in 1 of 3 subjects and significant improvements in manometric parameters were observed in all 5 subjects who underwent repeat anorectal manometry. We conclude that apomorphine can correct anorectal dysfunction in PD, and that these abnormalities may be a consequence of dopamine deficiency secondary to the PD process. These findings may also have therapeutic implications.

Original languageEnglish (US)
Pages (from-to)490-493
Number of pages4
JournalAnnals of Neurology
Volume33
Issue number5
StatePublished - May 1993
Externally publishedYes

Fingerprint

Apomorphine
Parkinson Disease
Secondary Parkinson Disease
Dopamine Agents
Defecation
Manometry
Dopamine
Injections
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Edwards, L. L., Quigley, E. M. M., Harned, R. K., Hofman, R., & Pfeiffer, R. (1993). Defecatory function in Parkinson's disease: Response to apomorphine. Annals of Neurology, 33(5), 490-493.

Defecatory function in Parkinson's disease : Response to apomorphine. / Edwards, L. L.; Quigley, E. M M; Harned, R. K.; Hofman, Ruth; Pfeiffer, Ronald.

In: Annals of Neurology, Vol. 33, No. 5, 05.1993, p. 490-493.

Research output: Contribution to journalArticle

Edwards, LL, Quigley, EMM, Harned, RK, Hofman, R & Pfeiffer, R 1993, 'Defecatory function in Parkinson's disease: Response to apomorphine', Annals of Neurology, vol. 33, no. 5, pp. 490-493.
Edwards LL, Quigley EMM, Harned RK, Hofman R, Pfeiffer R. Defecatory function in Parkinson's disease: Response to apomorphine. Annals of Neurology. 1993 May;33(5):490-493.
Edwards, L. L. ; Quigley, E. M M ; Harned, R. K. ; Hofman, Ruth ; Pfeiffer, Ronald. / Defecatory function in Parkinson's disease : Response to apomorphine. In: Annals of Neurology. 1993 ; Vol. 33, No. 5. pp. 490-493.
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