Decreased dopamine transporters with age in healthy human subjects

N. D. Volkow, J. S. Fowler, G. J. Wang, J. Logan, D. Schlyer, R. MacGregor, Robert Hitzemann, A. P. Wolf

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21-63 years) using positron emission tomography and [11C]cocaine. The ratio of the distribution volume for [11C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p <0.0005). This results document an age-related decline in dopamine transporters in healthy individuals.

Original languageEnglish (US)
Pages (from-to)237-239
Number of pages3
JournalAnnals of Neurology
Volume36
Issue number2
DOIs
StatePublished - Aug 1994
Externally publishedYes

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Dopamine Plasma Membrane Transport Proteins
Healthy Volunteers
Cocaine
Basal Ganglia
Positron-Emission Tomography
Cerebellum
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Volkow, N. D., Fowler, J. S., Wang, G. J., Logan, J., Schlyer, D., MacGregor, R., ... Wolf, A. P. (1994). Decreased dopamine transporters with age in healthy human subjects. Annals of Neurology, 36(2), 237-239. https://doi.org/10.1002/ana.410360218

Decreased dopamine transporters with age in healthy human subjects. / Volkow, N. D.; Fowler, J. S.; Wang, G. J.; Logan, J.; Schlyer, D.; MacGregor, R.; Hitzemann, Robert; Wolf, A. P.

In: Annals of Neurology, Vol. 36, No. 2, 08.1994, p. 237-239.

Research output: Contribution to journalArticle

Volkow, ND, Fowler, JS, Wang, GJ, Logan, J, Schlyer, D, MacGregor, R, Hitzemann, R & Wolf, AP 1994, 'Decreased dopamine transporters with age in healthy human subjects', Annals of Neurology, vol. 36, no. 2, pp. 237-239. https://doi.org/10.1002/ana.410360218
Volkow ND, Fowler JS, Wang GJ, Logan J, Schlyer D, MacGregor R et al. Decreased dopamine transporters with age in healthy human subjects. Annals of Neurology. 1994 Aug;36(2):237-239. https://doi.org/10.1002/ana.410360218
Volkow, N. D. ; Fowler, J. S. ; Wang, G. J. ; Logan, J. ; Schlyer, D. ; MacGregor, R. ; Hitzemann, Robert ; Wolf, A. P. / Decreased dopamine transporters with age in healthy human subjects. In: Annals of Neurology. 1994 ; Vol. 36, No. 2. pp. 237-239.
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