Decreased dopamine transporters with age in healthy human subjects

N. D. Volkow; J. S. Fowler; G. J. Wang; J. Logan; D. Schlyer; R. MacGregor; R. Hitzemann; A. P. Wolf

doi:10.1002/ana.410360218

Decreased dopamine transporters with age in healthy human subjects

N. D. Volkow, J. S. Fowler, G. J. Wang, J. Logan, D. Schlyer, R. MacGregor, R. Hitzemann, A. P. Wolf

Research output: Contribution to journal › Article › peer-review

167 Scopus citations

Abstract

The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21–63 years) using positron emission tomography and [¹¹C]cocaine. The ratio of the distribution volume for [¹¹C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age‐related decline in dopamine transporters in healthy individuals.

Original language	English (US)
Pages (from-to)	237-239
Number of pages	3
Journal	Annals of Neurology
Volume	36
Issue number	2
DOIs	https://doi.org/10.1002/ana.410360218
State	Published - Aug 1994
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Decreased dopamine transporters with age in healthy human subjects",

abstract = "The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21–63 years) using positron emission tomography and [11C]cocaine. The ratio of the distribution volume for [11C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age‐related decline in dopamine transporters in healthy individuals.",

author = "Volkow, {N. D.} and Fowler, {J. S.} and Wang, {G. J.} and J. Logan and D. Schlyer and R. MacGregor and R. Hitzemann and Wolf, {A. P.}",

year = "1994",

month = aug,

doi = "10.1002/ana.410360218",

language = "English (US)",

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T1 - Decreased dopamine transporters with age in healthy human subjects

AU - Volkow, N. D.

AU - Fowler, J. S.

AU - Wang, G. J.

AU - Logan, J.

AU - Schlyer, D.

AU - MacGregor, R.

AU - Hitzemann, R.

AU - Wolf, A. P.

PY - 1994/8

Y1 - 1994/8

N2 - The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21–63 years) using positron emission tomography and [11C]cocaine. The ratio of the distribution volume for [11C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age‐related decline in dopamine transporters in healthy individuals.

AB - The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21–63 years) using positron emission tomography and [11C]cocaine. The ratio of the distribution volume for [11C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age‐related decline in dopamine transporters in healthy individuals.

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VL - 36

SP - 237

EP - 239

JO - Annals of Neurology

JF - Annals of Neurology

IS - 2

ER -

Decreased dopamine transporters with age in healthy human subjects

Abstract

ASJC Scopus subject areas

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