Damage to Isolated Hearts by Oxygenators

A. Hedley Brown, Nelson R. Niles, Mark V. Braimbridge, W. Gerald Austen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The developed tension, compliance, and contractile velocity of isolated isovolumetric canine hearts, with myocardial biopsies examined by succinic dehydrogenase, acid hematein, and birefringence techniques, have been employed to investigate currently used perfusion methods. Ten isolated hearts perfused from a standard oxygenator, 11 from a mini-oxygenator, 12 from an oxygenator perfusing the whole body as well as the heart, and 12 cross-perfused from another dog were thus compared. Performance tests showed cross-perfusion to be the least damaging, followed by whole-body perfusion plus oxygenator, perfusion with the large oxygenator, and perfusion with the mini-oxygenator, in that order. Histochemistry showed deterioration of the oxygenator-supported hearts, but there was no deterioration in those supported by cross-perfusion. The cross-perfused isolated isovolumetric heart should thus be a good model for prolonged tests involving ventricular function. Drill biopsy appears to be a reasonable method for detecting early myocardial damage.

Original languageEnglish (US)
Pages (from-to)575-588
Number of pages14
JournalAnnals of Thoracic Surgery
Issue number6
StatePublished - 1972
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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