Cytomegaloviral hypophysitis in a simian immunodeficiency virus-infected rhesus macaque (Macacca mulatta)

Melissa R. Berg, Michael A. Owston, Marie Claire Gauduin, Basel Assaf, Anne Lewis, Edward J. Dick

Research output: Contribution to journalArticle

Abstract

Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.

Original languageEnglish (US)
JournalJournal of Medical Primatology
DOIs
Publication statusAccepted/In press - 2017

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Keywords

  • Cytomegalovirus
  • Inclusions
  • Intra-cytoplasmic
  • Intranuclear
  • Model
  • Non-human primate
  • Pituitary
  • Viral

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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