Cytogenetics of uterine sarcomas: Presentation of eight new cases and review of the literature

Mariola Iliszko, Nils Mandahl, Krzysztof Mrózek, Andrzej Denis, Nikos Pandis, Tania Pejovic, Malgorzata S. Babińska, Boguslaw S. Nedoszytko, Jaroslaw S. Debniak, Janusz Emerich, Maria Hrabowska, Clara D. Bloomfield, Janusz Limon

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Tissue from 14 uterine tumor samples from eight patients-four with endometrial stromal sarcoma (ESS), two with leiomyosarcoma (ULMS), and two with malignant mixed mesodermal tumor (MMMT)-were investigated cytogenetically after short-term culturing. Clonal chromosome aberrations were found in 12 tumors. One ESS showed a recombination between 7p14 and 17q12, a rearrangement characterizing a subset of ESSs. In our series, chromosomes 1, 6, 7, and 16 were involved in structural aberrations most frequently (four cases each). Net loss of 6q material was found in four cases and bands 11q13, 16q13, and 22q13 were each rearranged in four cases. Among 43 uterine sarcomas, including 12 MMTs, now available for evaluation, some differences in breakpoint distribution among different tumor types were found. Rearrangements of bands 1p32, 3p24, and 10q22 were found exclusively in ULMS, whereas aberrations of bands 6p21, 7p21, and 17q12 were found predominantly in ESS.

Original languageEnglish (US)
Pages (from-to)172-176
Number of pages5
JournalGynecologic oncology
Volume71
Issue number2
DOIs
StatePublished - Nov 1998

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Iliszko, M., Mandahl, N., Mrózek, K., Denis, A., Pandis, N., Pejovic, T., Babińska, M. S., Nedoszytko, B. S., Debniak, J. S., Emerich, J., Hrabowska, M., Bloomfield, C. D., & Limon, J. (1998). Cytogenetics of uterine sarcomas: Presentation of eight new cases and review of the literature. Gynecologic oncology, 71(2), 172-176. https://doi.org/10.1006/gyno.1998.5165