Cyclooxygenase-2 gene expression in human breast cancer

Michelle L. Parkett; Randall E. Harris; Farahnaz S. Joarder; Mary S. Ross; Kathryn P. Clausen; Fredika M. Robertson

Cyclooxygenase-2 gene expression in human breast cancer

Michelle L. Parkett, Randall E. Harris, Farahnaz S. Joarder, Mary S. Ross, Kathryn P. Clausen, Fredika M. Robertson

Research output: Contribution to journal › Article › peer-review

Abstract

Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p < 0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.

Original language	English (US)
Pages (from-to)	503-507
Number of pages	5
Journal	International Journal of Oncology
Volume	10
Issue number	3
State	Published - Mar 1 1997
Externally published	Yes

Keywords

COX-2
breast cancer
cyclooxygenase
nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Cyclooxygenase-2 gene expression in human breast cancer",

abstract = "Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p < 0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.",

keywords = "COX-2, breast cancer, cyclooxygenase, nonsteroidal anti-inflammatory drugs",

author = "Parkett, {Michelle L.} and Harris, {Randall E.} and Joarder, {Farahnaz S.} and Ross, {Mary S.} and Clausen, {Kathryn P.} and Robertson, {Fredika M.}",

year = "1997",

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T1 - Cyclooxygenase-2 gene expression in human breast cancer

AU - Parkett, Michelle L.

AU - Harris, Randall E.

AU - Joarder, Farahnaz S.

AU - Ross, Mary S.

AU - Clausen, Kathryn P.

AU - Robertson, Fredika M.

PY - 1997/3/1

Y1 - 1997/3/1

N2 - Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p < 0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.

AB - Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p < 0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.

KW - COX-2

KW - breast cancer

KW - cyclooxygenase

KW - nonsteroidal anti-inflammatory drugs

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Cyclooxygenase-2 gene expression in human breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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