Cyclooxygenase-2 gene expression in human breast cancer

Michelle L. Parkett, Randall E. Harris, Farahnaz S. Joarder, Mary S. Ross, Kathryn P. Clausen, Fredika M. Robertson

Research output: Contribution to journalArticle

250 Scopus citations

Abstract

Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p < 0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.

Original languageEnglish (US)
Pages (from-to)503-507
Number of pages5
JournalInternational Journal of Oncology
Volume10
Issue number3
StatePublished - Mar 1 1997

Keywords

  • COX-2
  • breast cancer
  • cyclooxygenase
  • nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Parkett, M. L., Harris, R. E., Joarder, F. S., Ross, M. S., Clausen, K. P., & Robertson, F. M. (1997). Cyclooxygenase-2 gene expression in human breast cancer. International Journal of Oncology, 10(3), 503-507.