Cyclooxygenase-2 gene expression in human breast cancer

Michelle L. Parkett, Randall E. Harris, Farahnaz Joarder, Mary S. Ross, Kathryn P. Clausen, Fredika M. Robertson

Research output: Contribution to journalArticle

248 Citations (Scopus)

Abstract

Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p <0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.

Original languageEnglish (US)
Pages (from-to)503-507
Number of pages5
JournalInternational Journal of Oncology
Volume10
Issue number3
StatePublished - Mar 1997
Externally publishedYes

Fingerprint

Cyclooxygenase 2
Breast Neoplasms
Gene Expression
Prostaglandin-Endoperoxide Synthases
Prostaglandins
Neoplasms
Protein Isoforms
Breast
Anti-Inflammatory Agents
Cell Count
Biomarkers
Enzymes
Pharmaceutical Preparations
Genes
Proteins

Keywords

  • breast cancer
  • COX-2
  • cyclooxygenase
  • nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Parkett, M. L., Harris, R. E., Joarder, F., Ross, M. S., Clausen, K. P., & Robertson, F. M. (1997). Cyclooxygenase-2 gene expression in human breast cancer. International Journal of Oncology, 10(3), 503-507.

Cyclooxygenase-2 gene expression in human breast cancer. / Parkett, Michelle L.; Harris, Randall E.; Joarder, Farahnaz; Ross, Mary S.; Clausen, Kathryn P.; Robertson, Fredika M.

In: International Journal of Oncology, Vol. 10, No. 3, 03.1997, p. 503-507.

Research output: Contribution to journalArticle

Parkett, ML, Harris, RE, Joarder, F, Ross, MS, Clausen, KP & Robertson, FM 1997, 'Cyclooxygenase-2 gene expression in human breast cancer', International Journal of Oncology, vol. 10, no. 3, pp. 503-507.
Parkett ML, Harris RE, Joarder F, Ross MS, Clausen KP, Robertson FM. Cyclooxygenase-2 gene expression in human breast cancer. International Journal of Oncology. 1997 Mar;10(3):503-507.
Parkett, Michelle L. ; Harris, Randall E. ; Joarder, Farahnaz ; Ross, Mary S. ; Clausen, Kathryn P. ; Robertson, Fredika M. / Cyclooxygenase-2 gene expression in human breast cancer. In: International Journal of Oncology. 1997 ; Vol. 10, No. 3. pp. 503-507.
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