Cyclic changes in HIV shedding from the female genital tract during the menstrual cycle

Marcel Curlin, Wanna Leelawiwat, Eileen F. Dunne, Wannee Chonwattana, Philip A. Mock, Famui Mueanpai, Sukhon Thep-Amnuay, Sara J. Whitehead, Janet M. McNicholl

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Factors increasing genital human immunodeficiency virus (HIV) shedding may increase female-to-male HIV transmission risk. We examined HIV shedding in 67 women with HIV type 1 and herpes simplex virus type 2 coinfection, during 2 menstrual cycles. Shedding occurred in 60%, 48%, and 54% of samples during the follicular, periovulatory, and luteal phases, respectively (P =. 01). Shedding declined after menses until ovulation, with a slope-0.054 log10 copies/swab/day (P 10 copies between peak and nadir levels. Shedding increased during the luteal phase only among women with CD4 counts of

Original languageEnglish (US)
Pages (from-to)1616-1620
Number of pages5
JournalJournal of Infectious Diseases
Volume207
Issue number10
DOIs
StatePublished - May 15 2013
Externally publishedYes

Fingerprint

Virus Shedding
Menstrual Cycle
Luteal Phase
HIV
Human Herpesvirus 2
Follicular Phase
Menstruation
CD4 Lymphocyte Count
Ovulation
Coinfection
HIV-1

Keywords

  • female
  • genital tract
  • HIV
  • menstrual cycle
  • mucosal
  • shedding
  • Thailand
  • transmission

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Curlin, M., Leelawiwat, W., Dunne, E. F., Chonwattana, W., Mock, P. A., Mueanpai, F., ... McNicholl, J. M. (2013). Cyclic changes in HIV shedding from the female genital tract during the menstrual cycle. Journal of Infectious Diseases, 207(10), 1616-1620. https://doi.org/10.1093/infdis/jit063

Cyclic changes in HIV shedding from the female genital tract during the menstrual cycle. / Curlin, Marcel; Leelawiwat, Wanna; Dunne, Eileen F.; Chonwattana, Wannee; Mock, Philip A.; Mueanpai, Famui; Thep-Amnuay, Sukhon; Whitehead, Sara J.; McNicholl, Janet M.

In: Journal of Infectious Diseases, Vol. 207, No. 10, 15.05.2013, p. 1616-1620.

Research output: Contribution to journalArticle

Curlin, M, Leelawiwat, W, Dunne, EF, Chonwattana, W, Mock, PA, Mueanpai, F, Thep-Amnuay, S, Whitehead, SJ & McNicholl, JM 2013, 'Cyclic changes in HIV shedding from the female genital tract during the menstrual cycle', Journal of Infectious Diseases, vol. 207, no. 10, pp. 1616-1620. https://doi.org/10.1093/infdis/jit063
Curlin, Marcel ; Leelawiwat, Wanna ; Dunne, Eileen F. ; Chonwattana, Wannee ; Mock, Philip A. ; Mueanpai, Famui ; Thep-Amnuay, Sukhon ; Whitehead, Sara J. ; McNicholl, Janet M. / Cyclic changes in HIV shedding from the female genital tract during the menstrual cycle. In: Journal of Infectious Diseases. 2013 ; Vol. 207, No. 10. pp. 1616-1620.
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