Abstract
Factors increasing genital human immunodeficiency virus (HIV) shedding may increase female-to-male HIV transmission risk. We examined HIV shedding in 67 women with HIV type 1 and herpes simplex virus type 2 coinfection, during 2 menstrual cycles. Shedding occurred in 60%, 48%, and 54% of samples during the follicular, periovulatory, and luteal phases, respectively (P =. 01). Shedding declined after menses until ovulation, with a slope-0.054 log10 copies/swab/day (P <. 001), corresponding to a change of approximately 0.74 log10 copies between peak and nadir levels. Shedding increased during the luteal phase only among women with CD4 counts of <350 cells/μL. In reproductive-aged women, shedding frequency and magnitude are greatest immediately following menses and lowest at ovulation.
Original language | English (US) |
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Pages (from-to) | 1616-1620 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 207 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2013 |
Externally published | Yes |
Keywords
- HIV
- Thailand
- female
- genital tract
- menstrual cycle
- mucosal
- shedding
- transmission
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases