Current approaches to medullary thyroid carcinoma, sporadic and familial

Elizabeth A. Fialkowski, Jeffrey F. Moley

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

Medullary thyroid carcinoma (MTC) is a rare malignancy of the thyroid C cells. It occurs in hereditary (25% of cases) and sporadic forms, and aggressiveness is related to the clinical presentation (hereditary vs. sporadic) and the type of RET mutation present. In hereditary cases, early diagnosis makes preventative surgery possible. In established cases, thorough surgical extirpation of the primary tumor and nodal metastases has been the mainstay of treatment. Radioactive iodine, external beam radiation therapy (EBRT), and conventional chemotherapy have not been effective. Newer systemic treatments, with agents that target abnormal RET proteins, hold promise and are being tested in clinical trials for patients with metastatic disease.

Original languageEnglish (US)
Pages (from-to)737-747
Number of pages11
JournalJournal of surgical oncology
Volume94
Issue number8
DOIs
StatePublished - Dec 15 2006

Keywords

  • Chemotherapy
  • MTC
  • Multiple endocrine neoplasia
  • RET tyrosine kinase
  • Thyroid cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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