Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: Implications for fertility preservation

II Smitz, M. M. Dolmans, J. Donnez, J. E. Fortune, O. Hovatta, K. Jewgenow, H. M. Picton, C. Plancha, L. D. Shea, Richard Stouffer, E. E. Telfer, T. K. Woodruff, Mary Zelinski

    Research output: Contribution to journalArticle

    199 Citations (Scopus)

    Abstract

    Background: Female cancer patients are offered 'banking' of gametes before starting fertility-threatening cancer therapy. Transplants of fresh and frozen ovarian tissue between healthy fertile and infertile women have demonstrated the utility of the tissue banked for restoration of endocrine and fertility function. Additional methods, like follicle culture and isolated follicle transplantation, are in development. methods: Specialist reproductive medicine scientists and clinicians with complementary expertise in ovarian tissue culture and transplantation presented relevant published literature in their field of expertise and also unpublished promising data for discussion. As the major aims were to identify the current gaps prohibiting advancement, to share technical experience and to orient new research, contributors were allowed to provide their opinioned expert views on future research. results: Normal healthy children have been born in cancer survivors after orthotopic transplantation of their cryopreserved ovarian tissue. Longevity of the graft might be optimized by using new vitrification techniques and by promoting rapid revascularization of the graft. For the in vitro culture of follicles, a successive battery of culture methods including the use of defined media, growth factors and three-dimensional extracellular matrix support might overcome growth arrest of the follicles. Molecular methods and immunoassay can evaluate stage of maturation and guide adequate differentiation. Large animals, including non-human primates, are essential working models. conclusions: Experiments on ovarian tissue from non-human primate models and from consenting fertile and infertile patients benefit from a multidisciplinary approach. The new discipline of oncofertility requires professionalization, multidisciplinarity and mobilization of funding for basic and translational research.

    Original languageEnglish (US)
    Article numberdmp056
    Pages (from-to)395-414
    Number of pages20
    JournalHuman Reproduction Update
    Volume16
    Issue number4
    DOIs
    StatePublished - Feb 1 2010

    Fingerprint

    Fertility Preservation
    Transplantation
    Transplants
    Primates
    Fertility
    Vitrification
    Reproductive Medicine
    Tissue Transplantation
    Neoplasms
    Translational Medical Research
    Immunoassay
    Germ Cells
    Extracellular Matrix
    Survivors
    Intercellular Signaling Peptides and Proteins
    Direction compound
    In Vitro Techniques
    Growth
    Research

    Keywords

    • Fertility preservation
    • Follicle
    • Oocyte
    • Tissue culture
    • Transplantation

    ASJC Scopus subject areas

    • Obstetrics and Gynecology
    • Reproductive Medicine

    Cite this

    Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation : Implications for fertility preservation. / Smitz, II; Dolmans, M. M.; Donnez, J.; Fortune, J. E.; Hovatta, O.; Jewgenow, K.; Picton, H. M.; Plancha, C.; Shea, L. D.; Stouffer, Richard; Telfer, E. E.; Woodruff, T. K.; Zelinski, Mary.

    In: Human Reproduction Update, Vol. 16, No. 4, dmp056, 01.02.2010, p. 395-414.

    Research output: Contribution to journalArticle

    Smitz, II, Dolmans, MM, Donnez, J, Fortune, JE, Hovatta, O, Jewgenow, K, Picton, HM, Plancha, C, Shea, LD, Stouffer, R, Telfer, EE, Woodruff, TK & Zelinski, M 2010, 'Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: Implications for fertility preservation', Human Reproduction Update, vol. 16, no. 4, dmp056, pp. 395-414. https://doi.org/10.1093/humupd/dmp056
    Smitz, II ; Dolmans, M. M. ; Donnez, J. ; Fortune, J. E. ; Hovatta, O. ; Jewgenow, K. ; Picton, H. M. ; Plancha, C. ; Shea, L. D. ; Stouffer, Richard ; Telfer, E. E. ; Woodruff, T. K. ; Zelinski, Mary. / Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation : Implications for fertility preservation. In: Human Reproduction Update. 2010 ; Vol. 16, No. 4. pp. 395-414.
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    AU - Fortune, J. E.

    AU - Hovatta, O.

    AU - Jewgenow, K.

    AU - Picton, H. M.

    AU - Plancha, C.

    AU - Shea, L. D.

    AU - Stouffer, Richard

    AU - Telfer, E. E.

    AU - Woodruff, T. K.

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