Cultured human skin: Heterotransplantation

Molly F. Kulesz-Martin, Arthur Birnkrant, William F. Mclimans

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We have reported that human skin, cultured in a controlled environment system (steady state), yields epidermis-like growth from adult donor split thickness specimens. A procedure for transplantation of such cellular outgrowths to athymic nude mice for functional and morphologic evaluations is reported. Successful transplants were definitively scored by the presence of histologic epidermal markers and human glucose phosphate isomerase. We suggest that the transplantation procedures reported here may contribute to the knowledge required for the use of autologous cultured skin in patients with large skin wounds.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalPathobiology
Volume50
Issue number4
DOIs
StatePublished - Jan 1 1982

Keywords

  • Human skin culture
  • Nude mice
  • Transplantation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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