CT Signs of Hepatofugal Portal Venous Flow in Patients with Cirrhosis

Thomas J. Bryce, Benjamin M. Yeh, Aliya Qayyum, Preeyacha Pacharn, Nathan M. Bass, Ying Lu, Fergus Coakley

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE. We investigated whether CT signs can be used to predict hepatofugal flow in the main portal vein in patients with cirrhosis. MATERIALS AND METHODS. We retrospectively identified 36 patients with cirrhosis, 18 with hepatopetal and 18 with hepatofugal flow in the main portal vein, who underwent contemporaneous abdominal sonography and CT. Two independent observers evaluated the following features on the randomized CT studies: diameter of the portal, splenic, and superior mesenteric veins; spleen size; and the presence of ascites, varices, or arterial phase portal venous enhancement. These data were correlated with the flow direction seen on sonography. RESULTS. A small main portal vein was the only sign significantly (p ≤ 0.05) predictive of hepatofugal flow by univariate and multivariate analyses. Observers 1 and 2 recorded a portal vein diameter of less than 1 cm in eight (44%) and seven (39%) of the 18 patients with hepatofugal flow compared with one (6%) and none of the 18 patients with hepatopetal flow, respectively (p <0.02). Receiver operating characteristic analysis using the size of the portal vein to predict flow direction revealed an area under the curve of 0.83 for observer 1 and 0.74 for observer 2. CONCLUSION. A diameter of less than 1 cm for the main portal vein is highly specific, although not sensitive, for hepatofugal portal venous flow in patients with cirrhosis. This sign may be useful when sonography is limited, or this sign may prompt sonographic assessment in patients not known to have hepatofugal flow.

Original languageEnglish (US)
Pages (from-to)1629-1633
Number of pages5
JournalAmerican Journal of Roentgenology
Volume181
Issue number6
StatePublished - Dec 2003
Externally publishedYes

Fingerprint

Portal Vein
Fibrosis
Ultrasonography
Mesenteric Veins
Varicose Veins
Ascites
ROC Curve
Area Under Curve
Spleen
Multivariate Analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Bryce, T. J., Yeh, B. M., Qayyum, A., Pacharn, P., Bass, N. M., Lu, Y., & Coakley, F. (2003). CT Signs of Hepatofugal Portal Venous Flow in Patients with Cirrhosis. American Journal of Roentgenology, 181(6), 1629-1633.

CT Signs of Hepatofugal Portal Venous Flow in Patients with Cirrhosis. / Bryce, Thomas J.; Yeh, Benjamin M.; Qayyum, Aliya; Pacharn, Preeyacha; Bass, Nathan M.; Lu, Ying; Coakley, Fergus.

In: American Journal of Roentgenology, Vol. 181, No. 6, 12.2003, p. 1629-1633.

Research output: Contribution to journalArticle

Bryce, TJ, Yeh, BM, Qayyum, A, Pacharn, P, Bass, NM, Lu, Y & Coakley, F 2003, 'CT Signs of Hepatofugal Portal Venous Flow in Patients with Cirrhosis', American Journal of Roentgenology, vol. 181, no. 6, pp. 1629-1633.
Bryce TJ, Yeh BM, Qayyum A, Pacharn P, Bass NM, Lu Y et al. CT Signs of Hepatofugal Portal Venous Flow in Patients with Cirrhosis. American Journal of Roentgenology. 2003 Dec;181(6):1629-1633.
Bryce, Thomas J. ; Yeh, Benjamin M. ; Qayyum, Aliya ; Pacharn, Preeyacha ; Bass, Nathan M. ; Lu, Ying ; Coakley, Fergus. / CT Signs of Hepatofugal Portal Venous Flow in Patients with Cirrhosis. In: American Journal of Roentgenology. 2003 ; Vol. 181, No. 6. pp. 1629-1633.
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N2 - OBJECTIVE. We investigated whether CT signs can be used to predict hepatofugal flow in the main portal vein in patients with cirrhosis. MATERIALS AND METHODS. We retrospectively identified 36 patients with cirrhosis, 18 with hepatopetal and 18 with hepatofugal flow in the main portal vein, who underwent contemporaneous abdominal sonography and CT. Two independent observers evaluated the following features on the randomized CT studies: diameter of the portal, splenic, and superior mesenteric veins; spleen size; and the presence of ascites, varices, or arterial phase portal venous enhancement. These data were correlated with the flow direction seen on sonography. RESULTS. A small main portal vein was the only sign significantly (p ≤ 0.05) predictive of hepatofugal flow by univariate and multivariate analyses. Observers 1 and 2 recorded a portal vein diameter of less than 1 cm in eight (44%) and seven (39%) of the 18 patients with hepatofugal flow compared with one (6%) and none of the 18 patients with hepatopetal flow, respectively (p <0.02). Receiver operating characteristic analysis using the size of the portal vein to predict flow direction revealed an area under the curve of 0.83 for observer 1 and 0.74 for observer 2. CONCLUSION. A diameter of less than 1 cm for the main portal vein is highly specific, although not sensitive, for hepatofugal portal venous flow in patients with cirrhosis. This sign may be useful when sonography is limited, or this sign may prompt sonographic assessment in patients not known to have hepatofugal flow.

AB - OBJECTIVE. We investigated whether CT signs can be used to predict hepatofugal flow in the main portal vein in patients with cirrhosis. MATERIALS AND METHODS. We retrospectively identified 36 patients with cirrhosis, 18 with hepatopetal and 18 with hepatofugal flow in the main portal vein, who underwent contemporaneous abdominal sonography and CT. Two independent observers evaluated the following features on the randomized CT studies: diameter of the portal, splenic, and superior mesenteric veins; spleen size; and the presence of ascites, varices, or arterial phase portal venous enhancement. These data were correlated with the flow direction seen on sonography. RESULTS. A small main portal vein was the only sign significantly (p ≤ 0.05) predictive of hepatofugal flow by univariate and multivariate analyses. Observers 1 and 2 recorded a portal vein diameter of less than 1 cm in eight (44%) and seven (39%) of the 18 patients with hepatofugal flow compared with one (6%) and none of the 18 patients with hepatopetal flow, respectively (p <0.02). Receiver operating characteristic analysis using the size of the portal vein to predict flow direction revealed an area under the curve of 0.83 for observer 1 and 0.74 for observer 2. CONCLUSION. A diameter of less than 1 cm for the main portal vein is highly specific, although not sensitive, for hepatofugal portal venous flow in patients with cirrhosis. This sign may be useful when sonography is limited, or this sign may prompt sonographic assessment in patients not known to have hepatofugal flow.

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