C5-curcuminoid-4-aminoquinoline based molecular hybrids: Design, synthesis and mechanistic investigation of anticancer activity

Shamseer Kulangara Kandi, Sunny Manohar, Christian E. Vélez Gerena, Beatriz Zayas, Sanjay V. Malhotra, Diwan S. Rawat

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The privileged scaffolds of curcumin and 4-aminoquinolines are extensively used in the design and synthesis of biodynamic agents having remarkable efficacy against diseases like cancer and malaria. Therefore, we anticipated that covalent hybridization of these two pharmacophores via the triazole linker may lead to molecules with better anticancer activity. The synthesized hybrid compounds were tested for their anti-cancer activity on 60 human cancer cell lines, which represent diverse histologies. Our study has identified a set of these hybrids that showed excellent growth inhibition at nano-molar concentrations. The mechanistic investigations through a series of assays showed apoptotic induction as a cause for their displayed anticancer activity.

Original languageEnglish (US)
Pages (from-to)224-234
Number of pages11
JournalNew Journal of Chemistry
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

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