Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure

Robert M. Bennett; James R. Lehr; Daniel J. McCarty

doi:10.1002/art.1780190116

Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure

Robert M. Bennett, James R. Lehr, Daniel J. McCarty

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Abstract

Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.

Original language	English (US)
Pages (from-to)	93-97
Number of pages	5
Journal	Arthritis & Rheumatism
Volume	19
Issue number	1
DOIs	https://doi.org/10.1002/art.1780190116
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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abstract = "Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.",

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AU - Lehr, James R.

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Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure

Abstract

ASJC Scopus subject areas

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