Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure

Robert M. Bennett, James R. Lehr, Daniel J. McCarty

    Research output: Contribution to journalArticle

    48 Scopus citations

    Abstract

    Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.

    Original languageEnglish (US)
    Pages (from-to)93-97
    Number of pages5
    JournalArthritis & Rheumatism
    Volume19
    Issue number1
    DOIs
    StatePublished - Jan 1 1976

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Rheumatology
    • Immunology
    • Pharmacology (medical)

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