Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure.

Robert (Rob) Bennett, J. R. Lehr, D. J. McCarty

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalArthritis and Rheumatism
Volume19
Issue number1
StatePublished - Jan 1976
Externally publishedYes

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Chondrocalcinosis
Therapeutic Irrigation
Knee Joint
Edetic Acid
Solubility
Therapeutics
Ions

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure. / Bennett, Robert (Rob); Lehr, J. R.; McCarty, D. J.

In: Arthritis and Rheumatism, Vol. 19, No. 1, 01.1976, p. 93-97.

Research output: Contribution to journalArticle

Bennett, RR, Lehr, JR & McCarty, DJ 1976, 'Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure.', Arthritis and Rheumatism, vol. 19, no. 1, pp. 93-97.
Bennett, Robert (Rob) ; Lehr, J. R. ; McCarty, D. J. / Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure. In: Arthritis and Rheumatism. 1976 ; Vol. 19, No. 1. pp. 93-97.
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