Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Vincent T. Bicocca, Bill Chang, Behzad Kharabi Masouleh, Markus Muschen, Marc Loriaux, Brian Druker, Jeffrey Tyner

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

We report that t(1;19) ALL cells universally exhibit expression of and dependence on the cell surface receptor ROR1. We further identify t(1;19) ALL cell sensitivity to the kinase inhibitor dasatinib due to its inhibition of the pre-B cell receptor (pre-BCR) signaling complex. These phenotypes are a consequence of developmental arrest at an intermediate/late stage of B-lineage maturation. Additionally, inhibition of pre-BCR signaling induces further ROR1 upregulation, and we identify distinct ROR1 and pre-BCR downstream signaling pathways that are modulated in a counterbalancing manner-both leading to AKT phosphorylation. Consistent with this, AKT phosphorylation is transiently eliminated after dasatinib treatment, but is partially restored following dasatinib potentiation of ROR1 expression. Consequently, ROR1 silencing accentuates dasatinib killing of t(1;19) ALL cells.

Original languageEnglish (US)
Pages (from-to)656-667
Number of pages12
JournalCancer Cell
Volume22
Issue number5
DOIs
StatePublished - Nov 13 2012

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Pre-B Cell Receptors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phosphorylation
Cell Surface Receptors
Phosphotransferases
Up-Regulation
Phenotype
Dasatinib

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia. / Bicocca, Vincent T.; Chang, Bill; Masouleh, Behzad Kharabi; Muschen, Markus; Loriaux, Marc; Druker, Brian; Tyner, Jeffrey.

In: Cancer Cell, Vol. 22, No. 5, 13.11.2012, p. 656-667.

Research output: Contribution to journalArticle

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