Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation

Soren Impey, Karl Obrietan, Scott T. Wong, Steve Poser, Shigetoshi Yano, Gary Wayman, Jean Christophe Deloulme, Guy Chan, Daniel R. Storm

Research output: Contribution to journalArticle

729 Scopus citations

Abstract

Although Ca2+-stimulated cAMP response element binding protein- (CREB- ) dependent transcription has been implicated in growth, differentiation, and neuroplasticity, mechanisms for Ca2+-activated transcription have not been defined. Here, we report that extracellular signal-related protein kinase (ERK) signaling is obligatory for Ca2+-stimulated transcription in PC12 cells and hippocampal neurons. The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB. Interestingly, the Ca2+-induced nuclear translocation of ERK and Rsk2 to the nucleus requires protein kinase A (PKA) activation. This may explain why PKA activity is required for Ca2+-stimulated CREB-dependent transcription. Furthermore, the full expression of the late phase of long-term potentiation (L-LTP) and L-LTP-associated CRE-mediated transcription requires ERK activation, suggesting that the activation of CREB by ERK plays a critical role in the formation of long lasting neuronal plasticity.

Original languageEnglish (US)
Pages (from-to)869-883
Number of pages15
JournalNeuron
Volume21
Issue number4
DOIs
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Neuroscience(all)

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    Impey, S., Obrietan, K., Wong, S. T., Poser, S., Yano, S., Wayman, G., Deloulme, J. C., Chan, G., & Storm, D. R. (1998). Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron, 21(4), 869-883. https://doi.org/10.1016/S0896-6273(00)80602-9