Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

Robert C. Bast, Ursula A. Matulonis, Anil K. Sood, Ahmed A. Ahmed, Adaobi E. Amobi, Frances R. Balkwill, Monicka Wielgos-Bonvallet, David D.L. Bowtell, James D. Brenton, Joan S. Brugge, Robert L. Coleman, Giulio F. Draetta, Kai Doberstein, Ronny I. Drapkin, Mark A. Eckert, Robert P. Edwards, Kevin M. Elias, Darren Ennis, Andrew Futreal, David M. GershensonRoger A. Greenberg, David G. Huntsman, Jennifer Xiao Ye Ji, Elise C. Kohn, Claudia Iavarone, Ernst R. Lengyel, Douglas A. Levine, Christopher J. Lord, Zhen Lu, Gordon B. Mills, Francesmary Modugno, Brad H. Nelson, Kunle Odunsi, Jessica A. Pilsworth, Robert K. Rottapel, Daniel J. Powell, Li Shen, Ie Ming Shih, David R. Spriggs, Josephine Walton, Kaiyang Zhang, Rugang Zhang, Lee Zou

    Research output: Contribution to journalComment/debate

    7 Scopus citations

    Abstract

    Substantial progress has been made in understanding ovarian cancer at the molecular and cellular level. Significant improvement in 5-year survival has been achieved through cytoreductive surgery, combination platinum-based chemotherapy, and more effective treatment of recurrent cancer, and there are now more than 280,000 ovarian cancer survivors in the United States. Despite these advances, long-term survival in late-stage disease has improved little over the last 4 decades. Poor outcomes relate, in part, to late stage at initial diagnosis, intrinsic drug resistance, and the persistence of dormant drug-resistant cancer cells after primary surgery and chemotherapy. Our ability to accelerate progress in the clinic will depend on the ability to answer several critical questions regarding this disease. To assess current answers, an American Association for Cancer Research Special Conference on “Critical Questions in Ovarian Cancer Research and Treatment” was held in Pittsburgh, Pennsylvania, on October 1-3, 2017. Although clinical, translational, and basic investigators conducted much of the discussion, advocates participated in the meeting, and many presentations were directly relevant to patient care, including treatment with poly adenosine diphosphate ribose polymerase (PARP) inhibitors, attempts to improve immunotherapy by overcoming the immune suppressive effects of the microenvironment, and a better understanding of the heterogeneity of the disease.

    Original languageEnglish (US)
    Pages (from-to)1963-1972
    Number of pages10
    JournalCancer
    Volume125
    Issue number12
    DOIs
    StatePublished - Jun 15 2019

    Keywords

    • PARP inhibitors
    • drug resistance
    • early detection
    • heterogeneity
    • immunotherapy
    • metabolism
    • microenvironment
    • ovarian cancer
    • prevention

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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  • Cite this

    Bast, R. C., Matulonis, U. A., Sood, A. K., Ahmed, A. A., Amobi, A. E., Balkwill, F. R., Wielgos-Bonvallet, M., Bowtell, D. D. L., Brenton, J. D., Brugge, J. S., Coleman, R. L., Draetta, G. F., Doberstein, K., Drapkin, R. I., Eckert, M. A., Edwards, R. P., Elias, K. M., Ennis, D., Futreal, A., ... Zou, L. (2019). Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer, 125(12), 1963-1972. https://doi.org/10.1002/cncr.32004