Corticotropin-releasing hormone: Clinical applications

L. K. Nieman, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Corticotropin-releasing hormone, a 41-amino-acid peptide, is an important hypothalamic factor regulating the pituitary secretion of adrenocorticotropic hormone (ACTH). This hormone, while rarely involved in the etiology of Cushing's syndrome, seems to play a major role in the pathogenesis of non-Cushing hypercortisolemic states. The administration of synthetic human and ovine CRH has been found useful in the differential diagnosis of Cushing's syndrome and in the preoperative localization of intrasellar ACTH-secreting tumors.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalAnnual Review of Medicine
Volume40
StatePublished - 1989
Externally publishedYes

Fingerprint

Cushing Syndrome
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Tumors
Sheep
Differential Diagnosis
Hormones
Amino Acids
Peptides
Neoplasms

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Corticotropin-releasing hormone : Clinical applications. / Nieman, L. K.; Loriaux, Donald (Lynn).

In: Annual Review of Medicine, Vol. 40, 1989, p. 331-339.

Research output: Contribution to journalArticle

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