Corticotropin-releasing hormone: Clinical applications

L. K. Nieman, D. L. Loriaux

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Corticotropin-releasing hormone, a 41-amino-acid peptide, is an important hypothalamic factor regulating the pituitary secretion of adrenocorticotropic hormone (ACTH). This hormone, while rarely involved in the etiology of Cushing's syndrome, seems to play a major role in the pathogenesis of non-Cushing hypercortisolemic states. The administration of synthetic human and ovine CRH has been found useful in the differential diagnosis of Cushing's syndrome and in the preoperative localization of intrasellar ACTH-secreting tumors.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalAnnual review of medicine
Volume40
DOIs
StatePublished - Jan 1 1989

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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