TY - JOUR
T1 - Corticotropin-releasing hormone
T2 - Clinical applications
AU - Nieman, L. K.
AU - Loriaux, D. L.
PY - 1989
Y1 - 1989
N2 - Corticotropin-releasing hormone, a 41-amino-acid peptide, is an important hypothalamic factor regulating the pituitary secretion of adrenocorticotropic hormone (ACTH). This hormone, while rarely involved in the etiology of Cushing's syndrome, seems to play a major role in the pathogenesis of non-Cushing hypercortisolemic states. The administration of synthetic human and ovine CRH has been found useful in the differential diagnosis of Cushing's syndrome and in the preoperative localization of intrasellar ACTH-secreting tumors.
AB - Corticotropin-releasing hormone, a 41-amino-acid peptide, is an important hypothalamic factor regulating the pituitary secretion of adrenocorticotropic hormone (ACTH). This hormone, while rarely involved in the etiology of Cushing's syndrome, seems to play a major role in the pathogenesis of non-Cushing hypercortisolemic states. The administration of synthetic human and ovine CRH has been found useful in the differential diagnosis of Cushing's syndrome and in the preoperative localization of intrasellar ACTH-secreting tumors.
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U2 - 10.1146/annurev.me.40.020189.001555
DO - 10.1146/annurev.me.40.020189.001555
M3 - Review article
C2 - 2543267
AN - SCOPUS:0024359489
SN - 0066-4219
VL - 40
SP - 331
EP - 339
JO - Annual review of medicine
JF - Annual review of medicine
ER -