Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis

Jack P. Rock, Edward H. Oldfield, Heinrich M. Schulte, Phillip W. Gold, Paul L. Kornblith, Lynn Loriaux, George P. Chrousos

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Abstract

Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 μg/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of this releasing factor and occurred without elevation of plasma concentrations of CRF, measured by radioimmunoassay. Thus, the cerebrospinal fluid (CSF) can serve as a conduit for delivery of CRF to the pituitary gland.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalBrain research
Volume323
Issue number2
DOIs
StatePublished - Dec 10 1984

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Keywords

  • ACTH
  • cerebrospinal fluid
  • corticotropin releasing factor
  • cortisol
  • tanycytes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Rock, J. P., Oldfield, E. H., Schulte, H. M., Gold, P. W., Kornblith, P. L., Loriaux, L., & Chrousos, G. P. (1984). Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis. Brain research, 323(2), 365-368. https://doi.org/10.1016/0006-8993(84)90315-9