Coronary bypass for stable angina. A prospective randomized study

F. E. Kloster, E. L. Kremkau, L. W. Ritzmann, S. H. Rahimtoola, Josef Rosch, P. H. Kanarek

Research output: Contribution to journalArticle

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Abstract

To evaluate the effects of coronary-artery bypass, 100 patients with stable, disabling angina were randomized to medical (49) or surgical (51) therapy. There was no statistical difference in major cardiac events after 3 yr (death in 5 medical vs. 4 surgical, infarction in 8 vs. 10, and unstable angina requiring operation or reoperation in 8 vs. 3 cases). Surgical patients with 3-vessel disease had fewer major events (P <0.05) than the comparable medical group and less unstable angina requiring operation (P <0.02). All unstable angina was less frequent in the surgical group (15 vs. 6, P <0.01). Functional classification improved more in surgical patients at 6 mth (P <0.01) and at late followup examination (P <0.05). After 6 mth, surgical patients achieved significantly higher exercise work loads (P <0.01), exercise heart rates (P <0.05), maximum paced heart rates (P <0.01) and myocardial lactate extraction (P <0.01). On the basis of this interim report of a relatively small group of patients, the authors conclude that bypass results in greater functional improvement and less unstable angina than medical therapy. The likelihood of death and myocardial infarction is unchanged by operation.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalNew England Journal of Medicine
Volume300
Issue number4
StatePublished - 1979

Fingerprint

Stable Angina
Unstable Angina
Prospective Studies
Heart Rate
Exercise
Workload
Reoperation
Coronary Artery Bypass
Infarction
Lactic Acid
Myocardial Infarction
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kloster, F. E., Kremkau, E. L., Ritzmann, L. W., Rahimtoola, S. H., Rosch, J., & Kanarek, P. H. (1979). Coronary bypass for stable angina. A prospective randomized study. New England Journal of Medicine, 300(4), 149-157.

Coronary bypass for stable angina. A prospective randomized study. / Kloster, F. E.; Kremkau, E. L.; Ritzmann, L. W.; Rahimtoola, S. H.; Rosch, Josef; Kanarek, P. H.

In: New England Journal of Medicine, Vol. 300, No. 4, 1979, p. 149-157.

Research output: Contribution to journalArticle

Kloster, FE, Kremkau, EL, Ritzmann, LW, Rahimtoola, SH, Rosch, J & Kanarek, PH 1979, 'Coronary bypass for stable angina. A prospective randomized study', New England Journal of Medicine, vol. 300, no. 4, pp. 149-157.
Kloster FE, Kremkau EL, Ritzmann LW, Rahimtoola SH, Rosch J, Kanarek PH. Coronary bypass for stable angina. A prospective randomized study. New England Journal of Medicine. 1979;300(4):149-157.
Kloster, F. E. ; Kremkau, E. L. ; Ritzmann, L. W. ; Rahimtoola, S. H. ; Rosch, Josef ; Kanarek, P. H. / Coronary bypass for stable angina. A prospective randomized study. In: New England Journal of Medicine. 1979 ; Vol. 300, No. 4. pp. 149-157.
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